http://strokeblog.strokeahajournal.org/2016/02/stereotactic-radiosurgery-leads-to-good.html
A Multicenter Study
- Dale Ding, MD;
- Robert M. Starke, MD, MSc;
- Hideyuki Kano, MD;
- David Mathieu, MD;
- Paul Huang, MD;
- Douglas Kondziolka, MD;
- Caleb Feliciano, MD;
- Rafael Rodriguez-Mercado, MD;
- Luis Almodovar, MD;
- Inga S. Grills, MD;
- Danilo Silva, MD;
- Mahmoud Abbassy, MD;
- Symeon Missios, MD;
- Gene H. Barnett, MD;
- L. Dade Lunsford, MD;
- Jason P. Sheehan, MD, PhD
+ Author Affiliations
- Correspondence to Jason Sheehan, MD, PhD, Department of Neurosurgery, University of Virginia, PO Box 800212, Charlottesville, VA 22908. E-mail jps2f@virginia.edu
Abstract
Background and Purpose—The
benefit of intervention for patients with unruptured cerebral
arteriovenous malformations (AVMs) was challenged by results
demonstrating superior clinical outcomes with
conservative management from A Randomized Trial of Unruptured Brain
AVMs (ARUBA).
The aim of this multicenter, retrospective
cohort study is to analyze the outcomes of stereotactic radiosurgery for
ARUBA-eligible
patients.
Methods—We combined
AVM radiosurgery outcome data from 7 institutions participating in the
International Gamma Knife Research Foundation.
Patients with ≥12 months of follow-up were
screened for ARUBA eligibility criteria. Favorable outcome was defined
as AVM obliteration,
no postradiosurgery hemorrhage, and no
permanently symptomatic radiation–induced changes. Adverse neurological
outcome was
defined as any new or worsening neurological
symptoms or death.
Results—The
ARUBA-eligible cohort comprised 509 patients (mean age, 40 years). The
Spetzler–Martin grade was I to II in 46% and III
to IV in 54%. The mean radiosurgical margin
dose was 22 Gy and follow-up was 86 months. AVM obliteration was
achieved in 75%.
The postradiosurgery hemorrhage rate during
the latency period was 0.9% per year. Symptomatic and permanent
radiation–induced
changes occurred in 11% and 3%, respectively.
The rates of favorable outcome, adverse neurological outcome, permanent
neurological
morbidity, and mortality were 70%, 13%, 5%,
and 4%, respectively.
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