Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, May 19, 2016

Dietary alpha-Lipoic Acid Impacts Brain Development of the Young Pig

We'll never know if this will help in stroke recovery because we have NO leaders to go to to update the stroke strategy and followup these simple questions with research. Myelination  may be impacted if we need myelination post-stroke
http://www.fasebj.org/content/30/1_Supplement/915.10.short
  1. Ryan N Dilger1
+ Author Affiliations
  1. 1Neuroscience Program, University of Illinois, Urbana, IL
  2. 2Pediatric Nutrition Institute, Mead Johnson Nutrition, Evansville, IN

Abstract

Alpha-lipoic acid (a-LA) is an antioxidant that has been shown to ameliorate age-associated impairments of brain and cardiovascular functions as well as diabetic neuropathy in rodents and humans. While the developing brain is highly metabolic and therefore potentially subject to periods of oxidative stress, relatively little is known about the extent to which antioxidants influence the developing brain. Using the preclinical piglet model, this exploratory study was designed to examine dose response effects of a-LA on growth, cognition and brain development. Beginning at 2 d of age, 31 male pigs received one of three diets formulated to contain: control (CONT) [0 mg a-LA/100g], low a-LA (LOW) [120 mg a-LA/100g], or high a-LA (HIGH) [240 mg a-LA/100g]. From 14 to 28 d of age, pigs were subjected to a spatial T-maze behavioral assessment and neuroimaging procedures were performed upon study completion at 31 d of age. No differences due to diets were observed in measures of small intestine weight or length, or brain volumes. Additionally, there was no observed interactive effect of diet x day for bodyweight measures. Spatial T-maze assessment did not reveal learning differences due to diet, however HIGH-fed piglets exhibited faster (P = 0.02) latency to choice compared with CONT and LOW-fed pigs on d 2 of the reversal phase. Neuroimaging analysis of microstructure using diffusion tensor imaging (DTI) revealed decreased (P = 0.01) fractional anisotropy (FA) in the internal capsule of HIGH-fed pigs, compared with CONT- and LOW-fed pigs. Moreover, internal capsule axial diffusivity values in HIGH-fed pigs were smaller (P < 0.01) than CONT pigs, but were not different from LOW-fed pigs. Tract-based spatial statistics (TBSS), which provide a voxel-wise comparison of FA values along pre-determined fiber tracts, revealed 4,116 voxels in which HIGH-fed pigs exhibited lower (P < 0.05) FA values compared with CONT pigs. Furthermore, TBSS revealed 7,105 voxels with lower (P < 0.05) FA values in HIGH-fed pigs compared with LOW-fed pigs. In both comparisons, the largest voxel-wise FA value differences were localized to areas of the internal capsule, further corroborating DTI observations. No TBSS differences were observed between CONT and LOW-fed pigs. Taken together, the DTI and TBSS data suggest an altered trajectory of brain white matter maturation in HIGH-fed piglets. In conclusion, lack of difference in growth, behavioral assessment, and neuroimaging outcomes between LOW and CONT pigs, indicate low concentrations of a-LA support normal development. Future research is warranted to determine if supplementation of low concentrations of a-LA may confer specific neurodevelopmental benefits to piglets exposed to hypoxia, oxidative or inflammatory stress during development. However, since supplementation at high concentrations may delay brain myelination future research should explore immunohistochemistry staining and/or electron microscopy in conjunction with longitudinal follow-up to better understand the implications of these findings.
Support or Funding Information
Supported by Mead Johnson Nutrition.

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