Deans' stroke musings: Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, May 17, 2016

Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats

Once again more research is needed. But we have NO stroke leadership or strategy to followup on any promising research. At least they used objective imaging to determine results.
http://ptjournal.apta.org/content/early/2016/05/11/ptj.20150504.abstract

Yuichi Sasaki, , , Masahito Nakazaki, Hiroshi Nagahama, Junpei Suzuki, Daiki Tateyama, Shinichi Oka, Takahiro Namioka, Ai Namioka, Rie Onodera, Takeshi Mikami, , Masafumi Kakizawa, Sumio Ishiai, Jeffery D. Kocsis, Osamu Honmou

DOI: 10.2522/ptj.20150504 Published May 12, 2016

Abstract

Background Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat stroke models. Rehabilitation therapy through physical exercise (Ex) also provides therapeutic efficacy for cerebral ischemia.

Objective The purpose of this study was to investigate whether synergic effects of daily rehabilitation and intravenous infusion of MSCs has therapeutic effects after stroke in rats.

Design This was an experimental study.

Methods A permanent middle cerebral artery occlusion (MCAO) was induced by intraluminal vascular occlusion with a microfilament. Four experimental groups were studied: Group 1 (Vehicle only: Vehicle), Group 2 (Vehicle + exercise: Vehicle + Ex), Group 3 (MSCs only: MSCs) and Group 4 (MSCs + Ex: Combined). Rat MSCs were intravenously infused at 6 hours after MCAO and the rats received daily rehabilitation with treadmill running exercise for 20 min. Lesion size was assessed at 1, 14, 35 days using MR imaging. Functional outcome was assessed using the limb placement test.

Results Both combined therapy and MSC infusion reduced lesion volume, induced synaptogenesis and elicited functional improvement compared with the groups without MSC infusion, but the effect was greater in the combined group.

Limitations A limitation of this study is that the results were limited to an animal model and cannot be generalized to humans.

Conclusions These data indicate that the combined therapy of daily rehabilitation and intravenous infusion of MSCs improved functional outcome in a rat MCAO model.