http://stroke.ahajournals.org/content/47/8/1997.abstract?etoc
A Simple and Accurate Prehospital Scale to Detect Large Vessel Occlusion Strokes
- Fabricio O. Lima, MD, MPH, PhD;
- Gisele S. Silva, MD, MPH, PhD;
- Karen L. Furie, MD, MPH;
- Michael R. Frankel, MD;
- Michael H. Lev, MD;
- Érica C.S. Camargo, MD, PhD, MSc;
- Diogo C. Haussen, MD;
- Aneesh B. Singhal, MD;
- Walter J. Koroshetz, MD;
- Wade S. Smith, MD;
- Raul G. Nogueira, MD
+ Author Affiliations
- Correspondence to Raul G. Nogueira, MD, 49 Jesse Hill Dr, SE Room No. 333, Atlanta, GA 30303. E-mail raul.g.nogueira@emory.edu
Abstract
Background and Purpose—Patients
with large vessel occlusion strokes (LVOS) may be better served by
direct transfer to endovascular capable centers
avoiding hazardous delays between primary and
comprehensive stroke centers. However, accurate stroke field triage
remains
challenging. We aimed to develop a simple
field scale to identify LVOS.
Methods—The Field
Assessment Stroke Triage for Emergency Destination (FAST-ED) scale was
based on items of the National Institutes
of Health Stroke Scale (NIHSS) with higher
predictive value for LVOS and tested in the Screening Technology and
Outcomes Project
in Stroke (STOPStroke) cohort, in which
patients underwent computed tomographic angiography within the first 24
hours of stroke
onset. LVOS were defined by total occlusions
involving the intracranial internal carotid artery, middle cerebral
artery-M1,
middle cerebral artery-2, or basilar
arteries. Patients with partial, bihemispheric, and anterior+posterior
circulation occlusions
were excluded. Receiver operating
characteristic curve, sensitivity, specificity, positive predictive
value, and negative
predictive value of FAST-ED were compared
with the NIHSS, Rapid Arterial Occlusion Evaluation (RACE) scale, and
Cincinnati
Prehospital Stroke Severity (CPSS) scale.
Results—LVO was
detected in 240 of the 727 qualifying patients (33%). FAST-ED had
comparable accuracy to predict LVO to the NIHSS
and higher accuracy than RACE and CPSS (area
under the receiver operating characteristic curve: FAST-ED=0.81 as
reference;
NIHSS=0.80, P=0.28; RACE=0.77, P=0.02; and CPSS=0.75, P=0.002).
A FAST-ED ≥4 had sensitivity of 0.60, specificity of 0.89, positive
predictive value of 0.72, and negative predictive
value of 0.82 versus RACE ≥5 of 0.55, 0.87,
0.68, and 0.79, and CPSS ≥2 of 0.56, 0.85, 0.65, and 0.78, respectively.
Conclusions—FAST-ED is a simple scale that if successfully validated in the field, it may be used by medical emergency professionals to
identify LVOS in the prehospital setting enabling rapid triage of patients.
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