http://www.mdlinx.com/neurology/top-medical-news/article/2016/07/20/6
Yale School of Medicine News
Rigid
thinking — or an inability to adapt to new information in the
environment — is a hallmark of schizophrenia and depression. Now a Yale
team headed by Alex Kwan from the Department of Psychiatry provides some
insights into what happens in the brain when flexible thinking is
required. Using fluorescent sensors to monitor brain activity in living
mice, the team noted distinct patterns of activity in the premotor
cortex when mice were confronted with different situations. If
confronted with familiar situations that favor internally guided action —
the human equivalent of looking left automatically when crossing the
street in the United States — activity change was gradual and late.
However in demanding situations that call for heeding sensory cues —
watching and listening for cars in unfamiliar country — neural activity
pattern shifts abruptly and early, even before a behavior change. The
changes were observable at the level of ensembles of individual brain
cells, as seen in neurons firing in the accompanying movie. “Plausibly,
the cognitive rigidity characteristic of disorders such as schizophrenia
could result from an inability of frontal cortical networks to shift or
maintain stable ensemble states,” the authors note. The findings were
published July 11 in the journal Nature Neuroscience.
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