So how much red wine should stroke patients be drinking to maybe solve this cause of the neuronal cascade of death? Does this also restore blood brain barrier integrity in stroke? Inquiring minds want to know.
Resveratrol appears to restore blood-brain barrier integrity in Alzheimer's disease
Georgetown University Medical Center News
Resveratrol,
given to Alzheimer’s patients, appears to restore the integrity of the
blood–brain barrier, reducing the ability of harmful immune molecules
secreted by immune cells to infiltrate from the body into brain tissues,
say researchers at Georgetown University Medical Center. The reduction
in neuronal inflammation slowed the cognitive decline of patients,
compared to a matching group of placebo–treated patients with the
disorder. The laboratory data provide a more complete picture of results
from a clinical trial studying resveratrol in Alzheimer’s disease that
was first reported in 2015. The new findings will be presented at the
Alzheimer’s Association International Conference 2016 in Toronto on July
27th. According to the researchers, this study suggests that some of
the immune molecules that can cause inflammation in the blood can enter
the brain through a leaky blood–brain barrier. “These findings suggest
that resveratrol imposes a kind of crowd control at the border of the
brain. The agent seems to shut out unwanted immune molecules that can
exacerbate brain inflammation and kill neurons,” says neurologist
Charbel Moussa, MD, PhD, scientific and clinical research director of
the GUMC Translational Neurotherapeutics Program. “These are very
exciting findings because it shows that resveratrol engages the brain in
a measurable way, and that the immune response to Alzheimer’s disease
comes, in part, from outside the brain.” In this new study, Moussa and
Turner found that treated patients had a 50 percent reduction in matrix
metalloproteinase–9 (MMP–9) levels in the cerebrospinal fluid. MMP–9 is
decreased when sirtuin1 (SIRT1) is activated. High levels of MMP–9 cause
a breakdown in the blood–brain barrier, allowing proteins and molecules
from the body to enter the brain. Normally low MMP–9 levels maintain
the barrier, say the researchers.
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