Deans' stroke musings: Hemodynamics and stroke risk in intracranial atherosclerotic disease

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, April 13, 2019

Hemodynamics and stroke risk in intracranial atherosclerotic disease

I have no clue what this means. You'll have to hope your doctor includes this in one of your stroke prevention protocols.

Hemodynamics and stroke risk in intracranial atherosclerotic disease

Annals of Neurology — Leng X, et al. | April 11, 2019

Using a computational fluid dynamics model, researchers ascertained if hemodynamic characteristics of symptomatic intracranial atherosclerotic stenosis (sICAS) are correlated with the risk of stroke relapse. The study sample consisted of 245 patients with acute ischemic stroke attributed to 50% to 99% ICAS, which was confirmed by computed tomographic angiography. Investigators found that the risk of recurrent ischemic stroke in the same territory was significantly higher for patients with both low-pressure ratio (PR=pressure_poststenotic/pressure_prestenotic) and high wall shear stress ratio (WSSR=WSS_{stenotic − throat}/WSS_prestenotic) vs those with normal PR and WSSR. This investigation represents a step forward in the study of intracranial atherosclerotic disease through the use of computational flow simulation techniques, showing a sICAS hemodynamic pattern that is more susceptible to stroke relapse and supporting hypoperfusion and artery-to-artery embolism as common ischemic stroke mechanisms in such patients.