The only thing that might have been somewhat high was my cholesterol, everything else was pretty much perfect at age 50. But with stroke that now throws everything out of whack.
Your chances of getting dementia.
1. A documented 33% dementia chance post-stroke from an Australian study? May 2012.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
3. A 20% chance in this research. July 2013.
4. Dementia Risk Doubled in Patients Following Stroke September 2018
5. Parkinson’s Disease May Have Link to Stroke March 2017
Optimal CV health at midlife reduces dementia risk
Patients aged 50 years
who adhered to recommendations from the American Heart Association’s
Life’s Simple 7 metric for CV health had a lower risk for dementia later
in life, according to a study published in The BMJ.
“Our findings suggest that the Life’s Simple 7, which comprises the cardiovascular health score, at age 50 may shape the risk of dementia in a synergistic manner,” Séverine Sabia, PhD, of the epidemiology department for aging and neurodegenerative diseases at the French National Institute of Health and Medical Research and department of epidemiology and public health at University College London, and colleagues wrote. “Cardiovascular risk factors are modifiable, making them strategically important prevention targets.”
Whitehall II study data
Researchers analyzed data from 7,899 participants from the Whitehall II study who were aged 50 years. Questionnaires and a clinical evaluation were conducted at baseline to assess anthropometric and CV measures, in addition to metabolic risk factors and diseases.
For this study, information on CV health metrics based on the AHA’s Life’s Simple 7 recommendations were assessed: BP, cholesterol, fasting glucose concentration, physical activity, diet, weight and smoking status. This information was used to calculate a CV health score that ranged from 0 to 14, with the highest score indicating better CV health. Poor CV health was defined as a score between 0 and 6, intermediate health was between 7 and 11 and optimal CV health was defined as a score between 12 and 14. Scores were also calculated for behavioral and biological metrics.
During a median follow-up of 24.7 years, 347 patients developed dementia.
The incidence rate of dementia in participants with poor CV health was 3.2 per 1,000 person-years (95% CI, 2.5-4). Compared with the poor CV health group, those with intermediate CV health had an absolute rate difference of –1.5 per 1,000 person-years (95% CI, –2.3 to –0.7). The absolute rate difference for participants with optimal CV health was –1.9 when compared with those with poor CV health (95% CI, –2.8 to –1.1).
Each point increase in the CV health score was associated with a lower risk for dementia (HR = 0.89; 95% CI, 0.85-0.95). This was also seen for each point increase in the behavioral score (HR = 0.87; 95% CI, 0.81-0.93) and biological score (HR = 0.91; 95% CI, 0.83-1).
The link between CV health at age 50 years and dementia was also observed in patients who did not develop CVD during follow-up (HR per 1-point increment in the CV health score = 0.89; 95% CI, 0.84-0.95).
“This study supports public health policies to improve cardiovascular health as early as age 50 to promote cognitive health,” Sabia and colleagues wrote.
Implications for clinical practice
“The implications from this study and many others are that the healthier the vascular system is in midlife, the lower the risk of subsequent dementia,” Carol Brayne, MD, director at the Institute of Public Health at University of Cambridge, and Fiona E. Matthews, PhD, professor of epidemiology at the Institute of Health and Society at University of Newcastle in the United Kingdom, wrote in a related editorial. – by Darlene Dobkowski
Disclosures: The authors of the study and the editorial report no relevant financial disclosures.
“Our findings suggest that the Life’s Simple 7, which comprises the cardiovascular health score, at age 50 may shape the risk of dementia in a synergistic manner,” Séverine Sabia, PhD, of the epidemiology department for aging and neurodegenerative diseases at the French National Institute of Health and Medical Research and department of epidemiology and public health at University College London, and colleagues wrote. “Cardiovascular risk factors are modifiable, making them strategically important prevention targets.”
Researchers analyzed data from 7,899 participants from the Whitehall II study who were aged 50 years. Questionnaires and a clinical evaluation were conducted at baseline to assess anthropometric and CV measures, in addition to metabolic risk factors and diseases.
For this study, information on CV health metrics based on the AHA’s Life’s Simple 7 recommendations were assessed: BP, cholesterol, fasting glucose concentration, physical activity, diet, weight and smoking status. This information was used to calculate a CV health score that ranged from 0 to 14, with the highest score indicating better CV health. Poor CV health was defined as a score between 0 and 6, intermediate health was between 7 and 11 and optimal CV health was defined as a score between 12 and 14. Scores were also calculated for behavioral and biological metrics.
During a median follow-up of 24.7 years, 347 patients developed dementia.
The incidence rate of dementia in participants with poor CV health was 3.2 per 1,000 person-years (95% CI, 2.5-4). Compared with the poor CV health group, those with intermediate CV health had an absolute rate difference of –1.5 per 1,000 person-years (95% CI, –2.3 to –0.7). The absolute rate difference for participants with optimal CV health was –1.9 when compared with those with poor CV health (95% CI, –2.8 to –1.1).
Each point increase in the CV health score was associated with a lower risk for dementia (HR = 0.89; 95% CI, 0.85-0.95). This was also seen for each point increase in the behavioral score (HR = 0.87; 95% CI, 0.81-0.93) and biological score (HR = 0.91; 95% CI, 0.83-1).
The link between CV health at age 50 years and dementia was also observed in patients who did not develop CVD during follow-up (HR per 1-point increment in the CV health score = 0.89; 95% CI, 0.84-0.95).
“This study supports public health policies to improve cardiovascular health as early as age 50 to promote cognitive health,” Sabia and colleagues wrote.
Implications for clinical practice
“The implications from this study and many others are that the healthier the vascular system is in midlife, the lower the risk of subsequent dementia,” Carol Brayne, MD, director at the Institute of Public Health at University of Cambridge, and Fiona E. Matthews, PhD, professor of epidemiology at the Institute of Health and Society at University of Newcastle in the United Kingdom, wrote in a related editorial. – by Darlene Dobkowski
Disclosures: The authors of the study and the editorial report no relevant financial disclosures.
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