Deans' stroke musings: Brain oscillatory activity as a biomarker of motor recovery in chronic stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, December 4, 2019

Brain oscillatory activity as a biomarker of motor recovery in chronic stroke

And how precisely will this get survivors recovered? Biomarkers are fucking useless to survivors.

Brain oscillatory activity as a biomarker of motor recovery in chronic stroke

Andreas M. Ray1| Thiago D. C. Figueiredo1| Eduardo López-Larraz1|Niels Birbaumer1| Ander Ramos-Murguialday1,21Institute of Medical Psychology andBehavioral Neurobiology, University ofTübingen, Tübingen, GermanyTECNALIA, Health Department, NeuralEngineering Laboratory, San Sebastián, SpainCorrespondenceAndreas M. Ray, Institute of MedicalPsychology and Behavioral Neurobiology,University of Tübingen, Silcherstraße5, Tübingen 72076, Germany.Email: andreas.ray@uni-tuebingen.deFunding informationBundesministerium für Bildung und Forschung,Grant/Award Numbers: 13GW0053,16SV7754; DeutscheForschungsgemeinschaft; DeutscherAkademischer Austauschdienst, Grant/AwardNumber: 91563355

Abstract

In the present work, we investigated the relationship of oscillatory sensorimotor patients with severe upper-limb paralysis are the basis of the observational study presented here. These patients underwent an intervention including movement training based on combined brain–machine interfaces and physiotherapy of several weeks recorded in a double-blinded randomized clinical trial. We analyzed the alpha oscillations over the motor cortex of 22 of these patients employing multilevel linear predictive mode alpha desynchronization during rehabilitative intervention and clinical improvement. Moreover, we observed that the initial alpha desynchronization conditions its modulation during intervention: Patients showing a strong alpha desynchronization at the beginning of the training improved if they increased their alpha desynchronization. Patients showing a small alpha desynchronization at initial training stages improved if they decreased it further on both hemispheres. In all patients, a progressive shift of desynchronization toward the ipsilesional hemisphere correlates significantly with clinical improvement regardless of lesion location. The results indicate that initial alpha desynchronization might be key for stratification of patients undergoing BMI interventions and that its interhemispheric balance plays an important role in motor recovery.