Wrong endpoint, stroke survivors care not one fucking bit about reperfusion. ARE YOU THAT FUCKING STUPID? 100% RECOVERY IS THE ONLY GOAL IN STROKE!
Oops, I'm not playing by the polite rules of Dale Carnegie, 'How to Win Friends and Influence People'.
Politeness
will never solve anything in stroke.
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and GSR Investigators
Abstract
Background and Purpose—
Stroke
etiology drives thrombus composition. We thus hypothesized that
endovascular treatment shows different efficacy in cardioembolic versus
noncardioembolic large-vessel occlusions (LVOs).
Methods—
Procedural
characteristics, grade of reperfusion, and functional outcome at
discharge and 90 days were compared between patients with cardioembolic
versus noncardioembolic LVO from the GSR-ET (German Stroke
Registry–Endovascular Treatment; n=2589). To determine associations with
functional outcome, adjusted odds ratios and 95% CIs were calculated
using ordinal multivariable logistic regression models adjusting for
potential baseline confounder variables.
Results—
Endovascular treatment of cardioembolic LVO had a higher rate of successful reperfusion (85.6% versus 81.0%; P=0.002) and a higher rate of complete reperfusion after a single thrombectomy pass (45.7% versus 38.1%; P<0.001)
compared with noncardioembolic LVO. Cardioembolic LVO was associated
with better functional outcome at discharge (adjusted odds ratio, 1.61
[95% CI, 1.37–1.88]) and 90 days (adjusted odds ratio, 1.29 [95% CI,
1.09–1.53]). In mediation analysis, reperfusion explained 47% of the
effect of etiology on functional outcome at discharge.
Conclusions—
These
results provide evidence for higher efficacy of endovascular treatment
in cardioembolic LVO compared with noncardioembolic LVO.
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