Deans' stroke musings: The Bioactivity of Neuronal-Derived Nitric Oxide in Aging and Neurodegeneration: Switching Signaling to Degeneration

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, November 13, 2020

The Bioactivity of Neuronal-Derived Nitric Oxide in Aging and Neurodegeneration: Switching Signaling to Degeneration

What the fuck is this trying to say? Nitric oxide is extremely useful in relaxing the blood vessels and reducing blood pressure. Should I be taking foods that create nitric oxide? What? How much? How often? Answers to those questions are what we need researchers to focus on. AND THAT IS WHY WE NEED SURVIVORS IN CHARGE.

nitric oxide (100 posts)

C.F.Lourenço^a^c E.Cadenas^b R.M.Barbosa^a^c J.Laranjinha^a^c

https://doi.org/10.1016/j.freeradbiomed.2020.11.005 Get rights and content

Highlights

•: Changes in the bioactivity of .^•NO are central to the molecular pathways associated with brain aging and neurodegeneration, including neurometabolism, neurovascular coupling and neuroinflammation;
•: Bioactivity of .^•NO is shaped by the redox milieu in cells and tissues;
•: Monitoring .^•NO concentration Dynamics in brain tissue and in vivo can be achieved using electrochemical methods coupled to microelectrodes.

Abstract

The small and diffusible free radical nitric oxide (^•NO) has fascinated biological and medical sciences since it was promoted from atmospheric air pollutant to biological ubiquitous signaling molecule. Its unique physical chemical properties expand beyond its radical nature to include fast diffusion in aqueous and lipid environments and selective reactivity in a biological setting determined by bioavailability and reaction rate constants with biomolecules. In the brain, ^•NO is recognized as a key player in numerous physiological processes ranging from neurotransmission/neuromodulation to neurovascular coupling and immune response. Furthermore, changes in its bioactivity are central to the molecular pathways associated with brain aging and neurodegeneration. The understanding of ^•NO bioactivity in the brain, however, requires the knowledge of its concentration dynamics with high spatial and temporal resolution upon stimulation of its synthesis. Here we revise the understanding of the role of neuronal-derived ^•NO in brain physiology, aging and degeneration, focused on changes in the extracellular concentration dynamics of this free radical and the regulation of bioenergetic metabolism and neurovascular coupling.(Nothing here told us anything useful at all, What the fuck were you thinking when you wrote these lines?)