Your doctor can tell you about this if you use ITB. And look at the cannabinoid(marijuana) use.
Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report
Abstract
Multiple sclerosis (MS)-related spasticity
is associated with disability and impairment in quality of life. We
report on a
patient with secondary progressive MS and spastic
tetraparesis (Expanded Disability Status Scale score 8.5). The right arm
exhibited flexor spasticity resulting in functional
disability despite multimodal symptomatic treatment. Intrathecal
baclofen
led to side effects despite decreasing efficacy.
Low-dose nabiximols improved spasticity and function with recovery of
daily-life
activities and spasticity-related symptoms.
Reduction of intrathecal baclofen ameliorated adverse drug reactions.
Add-on cannabinoid
therapy was effective in therapy-refractory
spasticity with supra-additive effect in combining intrathecal baclofen
and nabiximols,
hypothetically explained by mutually complementing
mechanisms of action.
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