This is probably why the 1000 studies that worked in rodents but failed in humans, as Dr. Tymianski noted years ago. Inflammation is extremely important to figure out in the stroke aftermath.
AN INFLAMMATORY FINDING Mice Aren’t Men
A recent paper coauthored by associate professor of pediatrics H.
Shaw Warren does just that. In a study that involved
collaboration among more than a dozen institutions, Warren, an
expert in sepsis (see below), asked whether the bodies of mice
react to burns, blunt trauma, and infection the same way that
human bodies do. Examining the genetic signatures of response to
such assaults, the scientists found very little similarity
between the two species.
The finding is stunning because mice have long been considered a
model organism for researching drugs for use in people. The study
authors estimate that 150 potential treatments for severe
inflammation have been tested in people after being found to work
in mice—and in the human trials, not a single one worked.
Full article at the link.
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