Dr. Hua Pan needs to go back to the drawing board based on the research that just came out about inflammation in mice not correlating to humans.
http://www.medicalnewstoday.com/releases/259487.php
Heart disease and approximately half of all strokes are the results of advanced atherosclerosis
with damaged endothelium, the inner lining of blood vessels. In 2009,
the direct and indirect annual cost of heart disease and stroke was
approximately $312.6 billion. Projections are for the total cost of
heart disease to increase from $523 to $1.126 billion from 2013 to 2030.
And by 2030, it is expected that there will be more than 148 million of
the US population would have heart disease. Development of new
technologies for assessing and treating endothelium damage will help
reduce that financial burden as reduce the human health burden resulting
from atherosclerosis.
Dr. Hua Pan, Research Instructor in Medicine at Dr. Samuel Wickline's
Laboratory in Washington University School of Medicine, investigated
quantitative evaluation and developed novel therapies for endothelial
barrier damage. The evolution and severity of endothelium damage in
advanced atherosclerotic plaque remain unknown, in part because
quantifiable methods are lacking for its in vivo assessment. Her latest
study is the first to demonstrate, in a well-established atherosclerosis
mouse model, ApoE deficient mice, a multifunctional perfluorocarbon
(PFC) nanoparticle (NP) for quantification of endothelial damage as well
as targeted anti-inflammatory drug delivery to the endothelium damage
site.
The study, conducted in ApoE deficient mice, quantified endothelium
damage by using PFC NP retained in mouse aorta as surrogate. It
demonstrated the evolution and severity of endothelium damage in
correlation to the length of the animal fat-diet consumption. Moreover,
the same PFC NP loaded with anti-inflammatory drug, NF-κB inhibitor,
down-regulated inflammation.
Dr. Wickline noted, this finding provided a new avenue for defining
disease stage and for following therapy to heal dangerous
atherosclerotic plaques.
Her findings were presented during Experimental Biology 2013 in Boston, MA.
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