Deans' stroke musings: UW Spinoff Impel Neuropharma Passes Key Nose-to-Brain Clinical Trial

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, April 18, 2013

UW Spinoff Impel Neuropharma Passes Key Nose-to-Brain Clinical Trial

Our researchers should be jumping for joy. Now we just need our Great stroke association to push some of the 177 hyperacute possibilities thru this delivery method. With that in place we could significantly reduce the disability from strokes. Ask your doctor for their ideas on how to reduce stroke damage. If none are forthcoming, ask yourself why you are seeing someone so incurious.
Delivery time in 10-20 minutes. Now if you could objectively determine that an ischemic stroke occurred you could have tPA delivered via this method in the ambulance.
http://www.xconomy.com/seattle/2013/04/18/uw-spinoff-impel-neuropharma-passes-key-nose-to-brain-clinical-trial/
Seattle-based Impel Neuropharma has been working for five years to show it can quickly deliver drugs through the nose, directly to the brain, for the treatment of central nervous system disorders. The animal data so far has been encouraging, but now the company has got key confirmation that it can do its thing in human beings.
Impel, a University of Washington spinoff, is announcing today that it has gotten those positive results from a study of seven patients, which was supported by one of its pharmaceutical collaborators. Full details are being saved for a peer-reviewed publication, but Impel chief scientist John Hoekman says that the company’s nose-to-brain drug delivery device was able to propel a small peptide molecule deep into the upper nasal passages and to the brain stem at an “order of magnitude” greater concentration than a conventional nasal spray.
The study enrolled research subjects at the Lovelace Respiratory Research Institute in Albuquerque, NM, Hoekman says. Researchers used an off-the-shelf peptide (not an actual drug candidate), attached to a radioactive tracer molecule, and used noninvasive SPECT imaging technology to confirm that the drug was getting delivered to the brain. Volunteers in the study were able to self-administer the compound through the nose, and researchers saw it get delivered to the destination within 10 to 20 minutes, Hoekman says.

More at link.