http://www.neurology.org/content/82/17/1556.full
- Barbara S. Koppel, MD, FAAN,
- John C.M. Brust, MD, FAAN,
- Terry Fife, MD, FAAN,
- Jeff Bronstein, MD, PhD,
- Sarah Youssof, MD,
- Gary Gronseth, MD, FAAN and
- David Gloss, MD
- Correspondence to American Academy of Neurology: guidelines@aan.com
-
doi: 10.1212/WNL.0000000000000363 Neurology April 29, 2014 vol. 82 no. 17 1556-1563
- Abstract
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Abstract
Objective: To determine the efficacy of medical marijuana in several neurologic conditions.
Methods: We
performed a systematic review of medical marijuana (1948–November 2013)
to address treatment of symptoms of multiple sclerosis
(MS), epilepsy, and movement disorders. We
graded the studies according to the American Academy of Neurology
classification
scheme for therapeutic articles.
Results: Thirty-four studies met inclusion criteria; 8 were rated as Class I.
Conclusions: The
following were studied in patients with MS: (1) Spasticity: oral
cannabis extract (OCE) is effective, and nabiximols
and tetrahydrocannabinol (THC) are probably
effective, for reducing patient-centered measures; it is possible both
OCE and
THC are effective for reducing both
patient-centered and objective measures at 1 year. (2) Central pain or
painful spasms
(including spasticity-related pain, excluding
neuropathic pain): OCE is effective; THC and nabiximols are probably
effective.
(3) Urinary dysfunction: nabiximols is probably
effective for reducing bladder voids/day; THC and OCE are probably
ineffective
for reducing bladder complaints. (4) Tremor: THC
and OCE are probably ineffective; nabiximols is possibly ineffective.
(5)
Other neurologic conditions: OCE is probably
ineffective for treating levodopa-induced dyskinesias in patients with
Parkinson
disease. Oral cannabinoids are of unknown
efficacy in non–chorea-related symptoms of Huntington disease, Tourette
syndrome,
cervical dystonia, and epilepsy. The risks and
benefits of medical marijuana should be weighed carefully. Risk of
serious
adverse psychopathologic effects was nearly 1%. (I don't believe that, marijuana has never had any proven bad effects)
Comparative effectiveness of medical marijuana vs other therapies is
unknown
for these indications.
Are you refuting these 13 studies?.
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