NO stroke strategy or stroke leadership.
http://link.springer.com/article/10.1007/s12640-015-9590-4
Abstract
Life expectancy of
most human populations has greatly increased as a result of factors
including better hygiene, medical practice, and nutrition.
Unfortunately, as humans age, they become more prone to suffer from
neurodegenerative diseases and neurotoxicity. Polyphenols can be cheaply
and easily obtained as part of a healthy diet. They present a wide
range of biological activities, many of which have relevance for human
health. Compelling evidence has shown that dietary phytochemicals,
particularly polyphenols, have properties that may suppress
neuroinflammation and prevent toxic and degenerative effects in the
brain. The mechanisms by which polyphenols exert their action are not
fully understood, but it is clear that they have a direct effect through
their antioxidant activities. They have also been shown to modulate
intracellular signaling cascades, including the PI3K–Akt, MAPK, Nrf2,
and MEK pathways. Polyphenols also interact with a range of
neurotransmitters, illustrating that these compounds can promote their
health benefits in the brain through a direct, indirect, or complex
action. We discuss whether polyphenols obtained from diet or food
supplements are an effective strategy to prevent or treat
neurodegeneration. We also discuss the safety, mechanisms of action, and
the current and future relevance of polyphenols in clinical treatment
of neurodegenerative diseases. As populations age, it is important to
discuss the dietary strategies to avoid or counteract the effects of
incurable neurodegenerative disorders, which already represent an
enormous financial and emotional burden for health care systems,
patients, and their families.
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