http://journal.frontiersin.org/article/10.3389/fneur.2015.00241/full?
- 1Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
- 2Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Sir William Dunn School of Pathology, Oxford, UK
Introduction
The adult brain is highly adaptable, even after
injury it often exhibits an impressive capacity for reorganization.
Activity in the brain during sleep is thought to be critically involved
in supporting these processes of plasticity. Briefly, sleep can be
thought of as a state of consciousness, or alternations in
consciousness, which oscillates between states of reduced awareness of
external real-world stimuli to a complete loss of consciousness (1).
While the precise mechanisms have yet to be clearly defined, sleep has
been associated with many important functions, including those of the
immune and memory systems (2–5).
In memory, sleep is consistently attributed a particularly prominent
role in supporting time-sensitive processes associated with the
consolidation of memories. Consolidation here refers to dynamic
processes in the brain that occur after initial (“on-line”) memory
encoding takes place, such as when we practice a new skill. Subsequent
(“off-line”) mechanisms of consolidation serve to further process these
new memory traces, for instance, to enable the integration of knowledge
and long-term memory storage.
One reason memory consolidation may be particularly
important in a clinical context is because of how it applies to
neurological rehabilitation, such as motor recovery after lesion to the
brain. Here, the primary aim of physical rehabilitation is to facilitate
recovery of functional motor capacity after initial impairment. Another
way to look at physical rehabilitation, therefore, is as a form of
motor learning, or relearning, which in turn may tap into some of the
same processes of memory formation and consolidation as other forms of
procedural memory (6, 7).
Consequently, experimental insights into processes in the brain that
support motor memory are likely to have more wide-ranging application
that may benefit understanding and development of useful strategies for
improving long-term rehabilitative outcomes in the clinic. The primary
objective of this review is to provide an assimilation of current
evidence on the role of sleep in motor learning and to identify specific
factors of learning and consolidation that may have important
implications for rehabilitation. For the purposes of this review, we
will focus primarily on sleep-dependent motor memory with relevance to
physical rehabilitation after stroke, although many of the discussion
points included here will likely apply more broadly to other types of
memory and rehabilitation. Meanwhile, what is some of the evidence
linking sleep, in particular, to motor memory?
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