I wonder if this dose would be helpful in stroke subjects. Are you getting diagnosed with cognitive impairment just because you can't stay focused on a task? If I would have been tested during my first week in the hospital I would have been considered totally impaired. I fell asleep during a speech therapist session. Of course I had been awake for three straight days in the ER.
Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects
- Micha MM Wilhelmus1,3
- Justin L Hay1
- Rob GJA Zuiker1
- Pieter Okkerse1
- Christelle Perdrieu2
- Julien Sauser2
- Maurice Beaumont2
- Jeroen Schmitt2
- Joop MA van Gerven1⇑
- Beata Y Silber2
- 1Centre for Human Drug Research (CHDR), Leiden, the Netherlands
- 2Nestle Research Centre, Lausanne, Switzerland
- 3Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, the Netherlands
- Joop MA van Gerven, Centre for Human Drug Research (CHDR), Zernikedreef 8, 2333CL Leiden, The Netherlands. Email: JvanGerven@chdr.nl
Abstract
Caffeine induces positive effects on
sustained attention, although studies assessing the acute effects of low
caffeine dose
(<75 mg) on sustained attention are limited and
use short-term tests. Therefore, we investigated the acute effects of a
60
mg dose of caffeine on sustained attention in tests
lasting up to 45 minutes using 82 low or non-caffeine-consuming healthy
male (n=41) and female (n=41)
adults aged between 40 and 60 years. Vigilance was measured using
Mackworth Clock test, Rapid Visual Information Processing
Test, adaptive tracking test, saccadic eye movement
and attention switch test. Effects on mood and fatigue were analysed
using
Bond and Lader and Caffeine Research visual
analogue scales, and Samn–Perelli questionnaire. Saliva sampling was
performed
for both compliance and caffeine pharmacokinetic
analysis. Administration of a 60 mg caffeine dose resulted in a
significant
improvement in sustained attention compared with
the placebo. Also a significantly improved peak saccadic velocity and
reaction
time performance was found, and decreased error
rate. Significantly increased feelings of alertness, contentment and
overall
mood after caffeine treatment compared with placebo
were observed. This study demonstrated that in healthy adult subjects
oral administration of a single 60 mg caffeine dose
elicited a clear enhancement of sustained attention and alertness,
measured
both in multiple objective performances and in
subjective scales.
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