http://stroke.ahajournals.org/content/47/11/2689.abstract?etoc
The MESA (Multi-Ethnic Study of Atherosclerosis)
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Abstract
Background and Purpose—Hepatocyte
growth factor (HGF) is positively associated with ischemic and
hemorrhagic stroke risk factors. However, understanding the relation
between HGF and stroke is in its infancy. Therefore, we sought to
examine the association of circulating HGF with incident stroke using
data from the MESA (Multi-Ethnic Study of Atherosclerosis). We
hypothesized that circulating HGF would be positively associated with an
increased risk of stroke.
Methods—Participants
aged 45 to 84 years (n=6711) had HGF measured between 2000 and 2002 and
were followed for incident stroke through 2013 (n=233). Cox
proportional hazards regression was used to calculate hazard ratios and
95% confidence intervals for incident stroke. A secondary analysis
stratified results by adjudicated stroke type (n=183 ischemic; n=39
hemorrhagic; n=11 other).
Results—After
adjustment for potential confounding variables, risk of stroke was 17%
higher with each standard deviation increase in HGF (hazard ratio, 1.17;
95% confidence interval, 1.03–1.34). This association was mainly driven
by ischemic stroke and did not change on exclusion of cardioembolic
strokes, although the number of excluded cases was small. The few
hemorrhagic and other types of stroke were not associated with HGF.
Conclusions—Circulating
HGF was positively associated with the incidence of stroke in a
diverse, population-based cohort of men and women from the United
States. Our findings support the hypothesis that circulating HGF is a
marker of endothelial damage and suggest that HGF may have utility as a
prognostic marker of stroke risk.
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