- The physicians enrolled 1,166 stroke–free participants. (so useless information for stroke survivors)
- They evaluated carotid beta stiffness index (STIFF) by M-mode ultrasound of the common carotid artery and calculated as the ratio of the natural log of the difference between systolic and diastolic blood pressure over STRAIN, a ratio of the difference between carotid systolic and diastolic diameter (DD) divided by DD.
- They measured WMHV by fluid-attenuated inversion recovery MRI.
- They examined the associations of STIFF, DD, and STRAIN with WMHV using linear regression after adjusting for sociodemographic, lifestyle, and vascular risk factors.
- Larger carotid DD was significantly associated with greater log-WMHV (β = 0.09, p = 0.001) in a fully adjusted model.
- As per the outcomes, STIFF and STRAIN were not significantly correlated with WMHV.
- Among Hispanic participants, STRAIN (β = -1.78, p = 0.002) and DD (β = 0.11, p = 0.001) were both associated with greater log-WMHV, but not among black or white participants in adjusted analyses stratified by race–ethnicity.