Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, November 7, 2017

Blood Leaking Fibrinogen Is the Cause of Multiple Neurological Diseases

We  need to know how much damage there is to the myelin sheaths post-stroke so we can determine if the solution to this is required for stroke recovery.
https://www.labroots.com/trending/cardiology/7243/blood-leaking-fibrinogen-cause-multiple-neurological-diseases

WRITTEN BY: Kara Marker
3 10 412

The body has built-in mechanisms to handle brain injury, but when something disrupts the repair process, neurological diseases like multiple sclerosis (MS), stroke, and Alzheimer’s develop. With a new study published in the journal Neuron, scientists from the Gladstone Institutes discovered the role of a blood protein in blocking repair processes in the brain.
Low magnification micrograph of a vasculitic neuropathy. Credit: Wikimedia User Nephron
Low magnification micrograph of a vasculitic neuropathy. Credit: Wikimedia User Nephron
Without the myelin sheath, nerve fibers experience a plethora of problems centered around impaired signal transmission: cognition, sensation, movement, and more. When Gladstone researchers realized that it was the blood-clotting protein fibrinogen that was causing the repair problems, they set out to revolutionize the way scientists approach treating neurological disorders.
Fibrinogen, made in the liver, is one of 13 coagulation factors that promote blood clotting. In the right context, blood clotting can save lives by preventing excessive bleeding. In the wrong context, blood clotting can prevent the flow of blood, carrying oxygen and nutrients, to important bodily organs like the brain and heart.
They found that fibrinogen “leaks” into the central nervous system and disrupts the way nerve cells produce myelin, preventing repair. Normally, adult stem cells travel to damaged nerve sites and transform into new myelin-producing cells. However, fibrinogen prevents adult stem cells from making the reparative transition into myelin-producing cells.
"We thought it might be important to look instead at the toxic environment outside the cell, where blood proteins accumulate," explained senior investigator Katerina Akassoglou, PhD. "We realized that targeting the blood protein fibrinogen could open up the possibility for new types of therapies to promote brain repair."
Now that they know what’s stopping repair, scientists are hopeful that they can find a way to better approach treating neurological diseases like MS and Alzheimer’s.
“Repairing myelin by eliminating the toxic effects of vascular damage in the brain is a new frontier in disease therapeutics," said Gladstone’s Lennart Mucke, MD. "This study could change the way we think about how to repair the brain."
Sources: Gladstone Institutes, Healthline

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