You just might want your doctor and hospital to contact researchers to follow this up with human testing for the improvement of cognitive decline possibility. Up to you, YOUR HOSPITAL WILL DO NOTHING WITHOUT YOUR PRODDING.
Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders
Abstract
Glutathione
(GSH) is an important antioxidant found abundantly and synthesized
intracellularly in the cytosol in a tightly regulated fashion. It has
diverse physiological functions, including protection against reactive
oxygen species and nitrogen species, antioxidant defense as well as
maintenance of cellular thiol status. The human brain due to the high
oxygen consumption is extremely susceptible to the generation of
reactive oxygen species. GSH plays a paramount role in brain antioxidant
defense, maintaining redox homeostasis. The depletion of brain GSH has
also been observed from both autopsies as well as in vivo MRS studies
with aging and varied neurological disorders (Alzheimer's disease,
Parkinson's disease, etc.). Therefore, GSH enrichment using
supplementation is a promising avenue in the therapeutic development for
these neurological disorders. This review will enrich the information
on the importance of GSH synthesis, metabolism, functions,
compartmentation and inter-organ transport, structural conformations and
its quantitation via different techniques. The transportation of GSH in
the brain via different interventional routes and its potential role in
the development of therapeutic strategies for various brain disorders
is also addressed. Very recent study found significant improvement of
behavioral deficits including cognitive decline, depressive-like
behaviors, in APP (NL-G-F/NL-G-FG-) mice due to oral GSH administration.
This animal model study put an emergent need to complete GSH
supplementation trial in MCI and AD patients for cognitive improvement
as proposed earlier.
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