Deans' stroke musings: Review Article on adult neurogenesis in humans

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, April 25, 2020

Review Article on adult neurogenesis in humans

https://doi.org/10.1016/j.tria.2020.100074 Get rights and content

Under a Creative Commons license

open access

Highlights on adult neurogenesis in humans

•: Investigators have confirmed that neurogenesis occurs in discrete areas of the adult brain.
•: This occurs primarily in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus.
•: Growth factors, neurotrophins, cytokines and hormones are the major regulators of adult neurogenesis.
•: Much progress was made over the past decade on adult neurogenesis.

Abstract

The concept of neurogenesis in the adult human brain was conceived in the 1960s, revisited in the 1980s and confirmed in the 1990s. It was a controversial area of research due to methodological challenges. It is now widely accepted that new neurons are continually generated in specific regions in the adult brain. This occurs primarily in the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neuroblasts from the subventricular zone migrate along the rostral migratory stream into the olfactory bulb, whereas neuroblasts from the subgranular zone show relatively little migratory behavior, and differentiate into dentate gyrus granule cells. Growth factors, neurotrophins, cytokines, and hormones are also major regulators of adult neurogenesis.

Much progress was made over the past decade, but many questions were remain unanswered, new insights are emerging at a stunning rate and made the investigation of neurogenesis in the adult human brain an intense area of research. In this review, I tried to present recent research findings regarding basic concept, historical background, primary site, factors influencing, clinical implications and functions of adult neurogenesis. Literatures searched for this paper were carried out by accessing PubMed, Google scholar, Web of science and other databases.