Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, April 21, 2020

Advances in Studies on Stroke-Induced Secondary Neurodegeneration (SND) and Its Treatment

Your chances of getting dementia.


1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.


2. Then this study came out and seems to have a range from 17-66%. December 2013.


3. A 20% chance in this research.   July 2013.


4. Dementia Risk Doubled in Patients Following Stroke September 2018 


5. Parkinson’s Disease May Have Link to Stroke March 2017

Abstract 


BACKGROUND:
The occurrence of secondary neurodegeneration has been exclusively observed after the first incidence of stroke. In humans and rodents, post-stroke secondary neurodegeneration (SND) is an inevitable event that can lead to progressive neuronal loss at a region distant to initial infarct. SND can lead to cognitive and motor function impairment, finally causing dementia. The exact pathophysiology of the event is yet to be explored. It is seen that the thalami, in particular, are susceptible to cause SND. The reason behind this is because the thalamus functioning as the relay centre and is positioned as an interlocked structure with direct synaptic signaling connection with the cortex. As SND proceeds, accumulation of misfolded proteins and microglial activation are seen in the thalamus. This leads to increased neuronal loss and worsening of functional and cognitive impairment. 
OBJECTIVE:
There is a necessity of specific interventions to prevent post-stroke SND, which are not properly investigated to date owing to sparsely reproducible pre-clinical and clinical data. The basis of this review is to thoroughly investigate about post-stroke SND and its updated treatment approaches. 
METHOD:
Our article presents a detailed survey of advances in studies on stroke-induced secondary neurodegeneration (SND) and its treatment. 
RESULTS:
This article aims to put forward the pathophysiology of the progressive disease. We have also tabulated the latest treatment approaches along with different neuroimaging system that will be helpful for future reference to explore. 
CONCLUSION:
In this article, we have reviewed the available reports on SND pathophysiology, detection techniques and possible treatment modalities that have not been attempted till date.

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