Deans' stroke musings: Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, July 7, 2020

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

This might help researchers focus on next steps but for us right now this doesn't help at all. But the abbreviations and numbers must be important because they completely bamboozle laypersons. You try explaining to your doctor you want to increase these brain proteins. She will laugh in your face. I hate to think I will need to take a college level course in research statistics to understand this. Especially this P stuff; P = 7.35 × 10⁻⁹

P-Values and Statistical Significance | Simply Psychology

The latest here:

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons

Lei Yu, PhD^1,2; Shinya Tasaki, PhD^1,2; Julie A. Schneider, MD^1,2,3; et al Konstantinos Arfanakis, PhD^1,4,5; Duc M. Duong, PhD⁶; Aliza P. Wingo, MD^7,8; Thomas S. Wingo, MD^9,10; Nicola Kearns, PhD¹; Gregory R. J. Thatcher, PhD¹¹; Nicholas T. Seyfried, PhD⁶; Allan I. Levey, MD, PhD⁹; Philip L. De Jager, MD, PhD^12,13; David A. Bennett, MD^1,2

Author Affiliations

JAMA Psychiatry. Published online July 1, 2020. doi:10.1001/jamapsychiatry.2020.1807

Key Points
Question What cortical proteins are associated with cognitive resilience among community-dwelling older persons?
Finding This study leveraged data from 391 community-dwelling older persons to conduct a proteome-wide association analysis of the human dorsolateral prefrontal cortex. Eight cortical proteins were identified in association with cognitive resilience, of which a higher level of NRN1, ACTN4, EPHX4, RPH3A, SGTB, CPLX1, and SH3GL1 and a lower level of UBA1 were associated with greater resilience.
Meaning Identifying these cortical proteins provides a complementary approach to developing novel therapeutics for the treatment and prevention of Alzheimer disease and related dementias.

Abstract

Importance Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics for the treatment and prevention of Alzheimer disease and related dementias.
Objective To identify proteins associated with cognitive resilience via a proteome-wide association study of the human dorsolateral prefrontal cortex.
Design, Setting, and Participants This study used data from 391 community-dwelling older persons who participated in the Religious Orders Study and the Rush Memory and Aging Project. The Religious Orders Study began enrollment January 1, 1994, and the Rush Memory and Aging Project began enrollment September 1, 1997, and data were collected and analyzed through October 23, 2019.
Exposures Participants had undergone annual detailed clinical examinations, postmortem evaluations, and tandem mass tag proteomics analyses.
Main Outcomes and Measures The outcome of cognitive resilience was defined as a longitudinal change in cognition over time after controlling for common age-related neuropathologic indices, including Alzheimer disease, Lewy bodies, transactive response DNA-binding protein 43, hippocampal sclerosis, infarcts, and vessel diseases. More than 8000 high abundance proteins were quantified from frozen dorsolateral prefrontal cortex tissue using tandem mass tag and liquid chromatography-mass spectrometry.
Results There were 391 participants (273 women); their mean (SD) age was 79.7 (6.7) years at baseline and 89.2 (6.5) years at death. Eight cortical proteins were identified in association with cognitive resilience: a higher level of NRN1 (estimate, 0.140; SE, 0.024; P = 7.35 × 10⁻⁹), ACTN4 (estimate, 0.321; SE, 0.065; P = 9.94 × 10⁻⁷), EPHX4 (estimate, 0.198; SE, 0.042; P = 2.13 × 10⁻⁶), RPH3A (estimate, 0.148; SE, 0.031; P = 2.58 × 10⁻⁶), SGTB (estimate, 0.211; SE, 0.045; P = 3.28 × 10⁻⁶), CPLX1 (estimate, 0.136; SE, 0.029; P = 4.06 × 10⁻⁶), and SH3GL1 (estimate, 0.179; SE, 0.039; P = 4.21 × 10⁻⁶) and a lower level of UBA1 (estimate, −0.366; SE, 0.076; P = 1.43 × 10⁻⁶) were associated with greater resilience.
Conclusions and Relevance These protein signals may represent novel targets for the maintenance of cognition in old age.

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