46 pages for your doctor's edification.
Using Micro-Ultrasound to Investigate the Effectiveness of Short-Term Rehabilitation following Focal Ischemic Stroke
A thesis submitted in conformity with the requirements
for the degree of Master of Science
Medical Biophysics
University of Toronto
© Copyright by Johnson Yu 2021
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Using Micro-Ultrasound to Investigate the Effectiveness of ShortTerm Rehabilitation following Focal Ischemic Stroke
Johnson Yu
Master of Science
Medical Biophysics
University of Toronto
2021
Abstract
Ischemic stroke leaves 40% of survivors with moderate to severe impairment.
Understanding how rehabilitation affects brain structure and function will be critical in its
effective application to individual patients and in its combination with promising new
interventions. In this work we investigated the impact of two weeks of skilled reaching
rehabilitation on motor function, cerebrovascular tortuosity, cerebral blood flow and neuronal
activity on a rodent model. Micro-ultrasound, intracerebral array electrophysiology and Montoya
staircase testing were used to characterize changes in the brain and motor function following
stroke. Perilesional vessels were significantly more tortuous than vessels in the contralesional
cortex with a further abolishment of hypercapnia-elicited homogenization of microbubble
velocities in perilesional arterioles. Rehabilitation significantly improved skilled reaching and
elevated neuronal power ratios. This current project highlights functional motor recovery and
neuronal plasticity in the subacute stage following stroke in the absence of cerebrovascular
changes using a dual imaging modality setup.
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