I'd fire anyone who came to me with useless recovery prediction research like this.
Accurate prediction of persistent upper extremity impairment in patients with ischemic stroke
Archives of Physical Medicine and Rehabilitation , Volume 103(5) , Pgs. 964-969.
NARIC Accession Number: J89032. What's this?
ISSN: 0003-9993.
Author(s): de Havenon, Adam; Heitsch, Laura; Sunmonu, Abimbola; Braun, Robynne; Lohse, Keith R.; Cole, John W.; Mistry, Eva; Lindgren, Arne; Worrall, Bradford B.; Cramer, Steven C..
Publication Year: 2022.
Number of Pages: 6.
Abstract: Study developed a simple and effective risk score for predicting which patients will have persistent impairment of upper-extremity motor function at 90 days post stroke. Data were analyzed for clinical trial patients hospitalized with acute ischemic stroke who were followed for 90 days to determine functional outcome; the cohort was divided into balanced derivation and validation samples. The primary outcome was persistent arm impairment, defined as a National Institutes of Health Stroke Scale (NIHSS) arm domain score of 2 to 4 at 90 days in patients who had a 24-hour NIHSS arm score of 1 or more. Least absolute shrinkage and selection operator regression were used to determine the elements of the persistent upper-extremity impairment (PUPPI) index. Analyses included 1,653 patients (827 derivation, 826 validation), of whom 803 (48.6 percent) had persistent arm impairment. The PUPPI index gives 1 point each for age 55 years or older and NIHSS values of worse arm, worse leg, facial palsy, and total NIHSS (≥10). The optimal cut point for the PUPPI index was 3 or greater, at which the area under the curve was greater than 0.75 for the derivation and validation cohorts and when using NIHSS values from either 24 hours or in a subacute or discharge time window. Results were similar across different levels of stroke severity. The PUPPI index can be administered in minutes and could be used as inclusion criterion in recovery-related clinical trials or, with additional development, as a prognostic tool for patients, caregivers, and clinicians.
Descriptor Terms: EVALUATION TECHNIQUES, FUNCTIONAL LIMITATIONS, LIMBS, MOBILITY IMPAIRMENTS, MOTOR SKILLS, OUTCOMES, PREDICTION, STROKE.
Can this document be ordered through NARIC's document delivery service*?: Y.
Citation: de Havenon, Adam, Heitsch, Laura, Sunmonu, Abimbola, Braun, Robynne, Lohse, Keith R., Cole, John W., Mistry, Eva, Lindgren, Arne, Worrall, Bradford B., Cramer, Steven C.. (2022). Accurate prediction of persistent upper extremity impairment in patients with ischemic stroke. Archives of Physical Medicine and Rehabilitation , 103(5), Pgs. 964-969. Retrieved 7/24/2022, from REHABDATA database.
NARIC Accession Number: J89032. What's this?
ISSN: 0003-9993.
Author(s): de Havenon, Adam; Heitsch, Laura; Sunmonu, Abimbola; Braun, Robynne; Lohse, Keith R.; Cole, John W.; Mistry, Eva; Lindgren, Arne; Worrall, Bradford B.; Cramer, Steven C..
Publication Year: 2022.
Number of Pages: 6.
Abstract: Study developed a simple and effective risk score for predicting which patients will have persistent impairment of upper-extremity motor function at 90 days post stroke. Data were analyzed for clinical trial patients hospitalized with acute ischemic stroke who were followed for 90 days to determine functional outcome; the cohort was divided into balanced derivation and validation samples. The primary outcome was persistent arm impairment, defined as a National Institutes of Health Stroke Scale (NIHSS) arm domain score of 2 to 4 at 90 days in patients who had a 24-hour NIHSS arm score of 1 or more. Least absolute shrinkage and selection operator regression were used to determine the elements of the persistent upper-extremity impairment (PUPPI) index. Analyses included 1,653 patients (827 derivation, 826 validation), of whom 803 (48.6 percent) had persistent arm impairment. The PUPPI index gives 1 point each for age 55 years or older and NIHSS values of worse arm, worse leg, facial palsy, and total NIHSS (≥10). The optimal cut point for the PUPPI index was 3 or greater, at which the area under the curve was greater than 0.75 for the derivation and validation cohorts and when using NIHSS values from either 24 hours or in a subacute or discharge time window. Results were similar across different levels of stroke severity. The PUPPI index can be administered in minutes and could be used as inclusion criterion in recovery-related clinical trials or, with additional development, as a prognostic tool for patients, caregivers, and clinicians.
Descriptor Terms: EVALUATION TECHNIQUES, FUNCTIONAL LIMITATIONS, LIMBS, MOBILITY IMPAIRMENTS, MOTOR SKILLS, OUTCOMES, PREDICTION, STROKE.
Can this document be ordered through NARIC's document delivery service*?: Y.
Citation: de Havenon, Adam, Heitsch, Laura, Sunmonu, Abimbola, Braun, Robynne, Lohse, Keith R., Cole, John W., Mistry, Eva, Lindgren, Arne, Worrall, Bradford B., Cramer, Steven C.. (2022). Accurate prediction of persistent upper extremity impairment in patients with ischemic stroke. Archives of Physical Medicine and Rehabilitation , 103(5), Pgs. 964-969. Retrieved 7/24/2022, from REHABDATA database.
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