Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, July 7, 2022

Personalised knowledge to reduce the risk of stroke (PERKS-International): protocol for a randomised controlled trial

 Where is the much more important research?

Personalised knowledge to 100% recovery

I would never approve research like this, the whole point of stroke research is to get survivors recovered. This is just a lazy way to get published. 

Shit there are multiple stroke risk calculators out there already, making it mobile is not addressing an unmet need. My parents could never have figured out a cell phone much less an app on that cell phone, which would be the market for such an app.

  • stroke risk calculator (24 posts to February 2011) And none of these had me at anything other than low risk, because they can't tell how unstable your plaque is. 

Personalised knowledge to reduce the risk of stroke (PERKS-International): protocol for a randomised controlled trial

First Published June 30, 2022 Research Article 

Abstract

Rationale

Theoretically, most strokes could be prevented through the management of modifiable risk factors. The Stroke Riskometer™ mobile phone application (hereon ‘The App’) uses an individual’s data to provide personalised information and advice to reduce their risk of stroke.

Aims

To determine the effect of The App on a combined cardiovascular risk score (Life’s Simple 7®, LS7) of modifiable risk factors at 6 months post-randomisation.

Methods and design

PERKS-International is a Phase III, multicentre, prospective, pragmatic, open-label, single-blinded endpoint, 2-arm randomised controlled trial (RCT). Inclusion criteria are: age ≥35 and ≤75 years; ≥2 LS7 risk factors; smartphone ownership; no history of stroke/myocardial infarction/cognitive impairment/terminal illness. The intervention group (IG) will be provided with The App and the usual care group (UCG) is provided with generic online information about risk factors, but not be informed about The App. Face-to-face assessments will be conducted at baseline and 6 months, and online at 3 and 12 months. The RCT includes a process and economic evaluation.

Study outcomes and sample size

The primary outcome is a difference in the mean change in LS7 (7 individual items: blood pressure, cholesterol, glucose, body mass index [BMI], smoking, physical activity and diet) from baseline to 6 months post-randomisation with intention-to-treat analysis. Secondary outcomes include: change in individual LS7 items, quality of life; stroke awareness, adverse events; health service use; and costs. Based on pilot data, 790 participants (395 IG, 395 UCG) will be required to provide 80% power (two sided α=0.05) to detect a mean difference in the LS7 of ≥0.40 (SD 1.61) in IG compared to 0.01 (SD 1.44) in the UCG at 6 months post-randomisation.

Discussion

Stroke is largely preventable. This study will provide evidence of the effectiveness of a mobile app to reduce stroke risk.

Trial registration

ACTRN12621000211864

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