Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, February 9, 2023

Medication that protects brain tissue linked to improved stroke survival

 But they don't say which of the 5 causes of the neuronal cascade of death  this is addressing.  So you lucked out with your research by flying blind. 

Neuroprotection means absolutely nothing to survivors, use the correct term; neuronal cascade of death; that at least confers some urgency. 'Why hasn't your doctor done anything to stop the neuronal cascade of death?'  Mine did nothing and as a result I lost an additional 4.5 billion neurons. At $1000 a lost neuron that would only cost the hospital 4.5 trillion dollars. THAT MIGHT ACTUALLY CAUSE THEM TO WORK ON SOLVING STROKE!

 

Medication that protects brain tissue linked to improved stroke survival

Research Highlights:

  • For the first time, a novel neuroprotectant medication that may safeguard the brain from tissue damage has been linked to reduced death and disability among people diagnosed with stroke when added to standard treatment to restore blood flow.

  • The rate of death was four times lower among people who received the neuroprotectant medication, ApTOLL, compared to those receiving a placebo in a multi-nation study.

Embargoed until 11:52 a.m. CT / 12:52 p.m. CT, Wednesday Feb. 8, 2023

(NewMediaWire) - February 08, 2023 - DALLAS The neuroprotectant ApTOLL, a medication that may shield the brain from tissue damage, was linked to reduced death and disability among people being treated for stroke when used with standard treatments to restore blood flow, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2023. The meeting, held in person in Dallas and virtually Feb. 8-10, 2023, is a world premier meeting for researchers and clinicians dedicated to the science of stroke and brain health.

"The results are promising because for the first time a medicine studied as a neuroprotectant demonstrated not only a biological benefit by reducing the volume of damaged brain tissue, but also a reduction in long term disability and risk of death," said study senior author Marc Rib, M.D., an interventional neurologist at Hospital Vall d'Hebron in Barcelona, Spain.

In this clinical trial, researchers investigated if the neuroprotective medication ApTOLL may improve outcomes among people with stroke who also received standard treatment. ApTOLL is a TOLL-like receptor 4 (TLR4) antagonist involved in immune responses, yet it also responds to tissue damage. Previous studies in animals found that ApTOLL reduced inflammation and protected brain tissue from damage. Also, a first-in-human study in healthy adults did not find safety issues with ApTOLL.

From July 2021 to April 2022, more than 150 adults diagnosed with stroke (average age 70 years) treated in 15 hospitals in France and Spain were randomly assigned to either 0.05mg/kg of ApTOLL, 0.2mg/kg of ApTOLL or a placebo.

Within six hours of symptom onset, all participants also received the standard ischemic stroke treatment to restore blood flow to the brain mechanical blood clot removal. This treatment, also called endovascular therapy, involves insertion of a tiny tube into the blood vessel to retrieve the blood clot. Study participants also may have received the clot-busting medication known as tPA if needed to help dissolve the clot.

Among the trial's findings:

  • The higher ApTOLL dose showed a neuroprotective effect while the lower dose did not show any effect compared to placebo.

  • Ninety days after treatment, death rates among participants who received the higher dose of ApTOLL were more than four times lower compared to those who received placebo: 4% versus 18%, respectively.

  • Imaging tests given 72 hours after treatment showed that the size of damaged brain tissue was reduced by 40% among the participants who received the higher dose of ApTOLL compared to the placebo group.

  • 64% of participants who received the higher dose of ApTOLL were free of disability at 90 days, compared to 47% of those in the placebo group.

"If the results are confirmed with larger studies, it will mean that we can effectively treat patients with neuroprotectants, in addition to current standard treatments to restore blood flow," said co-lead author Macarena Hernndez, Ph.D. "Both kinds of treatments may be combined, and neuroprotectants will buy time, reducing brain damage until blood flow is restored."

A study limitation is its small number of participants. Larger studies are in the planning stages, according to Rib.

The fifth-leading cause of death in the United States and a major cause of long-term disability, stroke caused more than 160,000 U.S. deaths in 2020, according to the 2023 American Heart Association Statistics.

Other study co-authors are Francisco Abad-Santos, M.D., Ph.D.; Ian Cotgreave, Ph.D.; Jaime Gallego Sr., M.D.; Bernd Jilma, M.D.; Alan Flores Flores, M.D., Ph.D.; Tudor G. Jovin, M.D.; Jos Vivancos,; M.D.; Maria Hernandez-Perez, M.D., Ph.D.; Carlos A. Molina, M.D.; Joan Montaner, M.D., Ph.D.; Joaquin Casariego, M.D.; Mads Dalsgaard, M.B.A., D.M.Sc., M.D.; David S. Liebeskind, M.D.; Erik Cobo, Ph.D.; Maria del Mar Castellanos, M.D.; Pedro Cardona, M.D.; Jaime Masjuan, M.D., Ph.D.; Francisco Moniche Sr., M.D., Ph.D.; Jose Tembl, M.D.; Mikel Terceo, M.D., Ph.D.; Juan F. Arenillas, M.D.; Patricia Calleja, M.D.; Lionel Calviere, M.D.; Jean Marc M. Olivot, Prof., M.D.; Hilde Henon, M.D.; and Mikael Mazighi, M.D., Ph.D. The list of authors' disclosures is available in the abstract.

AptaTargets S.L. funded the study.

Statements and conclusions of studies that are presented at the American Heart Association's scientific meetings are solely those of the study authors and do not necessarily reflect the Association's policy or position. The Association makes no representation or guarantee as to their accuracy or reliability. Abstracts presented at the Association's scientific meetings are not peer-reviewed, rather, they are curated by independent review panels and are considered based on the potential to add to the diversity of scientific issues and views discussed at the meeting. The findings are considered preliminary until published as a full manuscript in a peer-reviewed scientific journal.

The Association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and biotech companies, device manufacturers and health insurance providers and the Association's overall financial information are available here.

Additional Resources:

The American Stroke Association's International Stroke Conference (ISC) is the world's premier meeting dedicated to the science and treatment of cerebrovascular disease. ISC 2023 will be held in person in Dallas and virtually Feb. 8-10, 2023. The three-day conference will feature more than a thousand compelling presentations in categories that emphasize basic, clinical and translational sciences as research evolves toward a better understanding of stroke pathophysiology with the goal of developing more effective therapies. Engage in the International Stroke Conference on social media via #ISC23.

About the American Stroke Association

The American Stroke Association is devoted to saving people from stroke the No. 2 cause of death in the world and a leading cause of serious disability. We team with millions of volunteers to fund innovative research, fight for stronger public health policies and provide lifesaving tools and information to prevent and treat stroke. The Dallas-based association officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit stroke.org. Follow us on Facebook, Twitter.

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For Media Inquiries and AHA Expert Perspective:

AHA Communications & Media Relations in Dallas: 214-706-1173; ahacommunications@heart.org

Bridgette McNeill: 214-706-1173; Bridgette.mcneill@heart.org

For Public Inquiries: 1-800-AHA-USA1 (242-8721)

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