Deans' stroke musings: The relationship between rehabilitation outcomes and extracellular thiol-disulphide and intracellular oxidized-reduced glutathione homeostasis in patients with subacute stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, April 1, 2023

The relationship between rehabilitation outcomes and extracellular thiol-disulphide and intracellular oxidized-reduced glutathione homeostasis in patients with subacute stroke

Ask your doctors how they will use this to get you recovered. They don't know or even worse don't even know about the research. Then you don't have a functioning stroke doctor.

RUN AWAY!

The relationship between rehabilitation outcomes and extracellular thiol-disulphide and intracellular oxidized-reduced glutathione homeostasis inpatients with subacute stroke

1 Tugba Alisik, 2 Murat Alisik, 1 Sirzat Cogalgil
1 Physical Medicine and Rehabilitation, AIBU Izzet Baysal Physical Treatment and Rehabilitation
Training and Research Hospital, Bolu; 2 Medical Biochemistry, Bolu Abant Izzet Baysal University,
Bolu, Turkey

Abstract

Background & Objective:

To evaluate the relationship between the clinical outcome of subacute stroke
patients and extracellular thiol-disulphide (SH-SS) and intracellular oxidized-reduced glutathione
(GSSG-GSH) homeostasis and the effect of the rehabilitation program on these homeostasis. Methods:
In this prospective observational study, outcome assessments (National Institutes of Health Stroke
Scale Scores (NIHSS), modified Rankin Scale (mRS), and Barthel Daily Living Activities Index
(BI)) and SH-SS and GSSG-GSH homeostasis parameters were investigated from 42 patients with
subacute stroke before and after 4-week rehabilitation treatment protocol. Also, SH-SS and GSSG-GSH
homeostasis parameters were measured from 35 healthy volunteers.

Results:

SS/SH and GSSG/GSH
ratios were significantly higher in the patient group at baseline and post-rehabilitation than the control
group (p<0.05). SS/SH ratio, GSSG/GSH ratio, NIHSS and mRS values significantly decreased with
the rehabilitation (p<0.05). The baseline SS/SH and GSSG/GSH ratios were correlated with baseline
and post-rehabilitation NIHSS, mRS and BI scores (p<0.05).

Conclusions:

The better outcomes of patients with higher baseline antioxidant thiol groups suggest
that active thiol groups may play a role in achieving better outcomes in subacute stroke. In addition,
rehabilitation treatment increased clinical scores and additionally shifted intracellular and extracellular
thiol groups to the antioxidant side.