Deans' stroke musings: Faster Reperfusion Linked to Better Stroke Recovery

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, July 26, 2025

Faster Reperfusion Linked to Better Stroke Recovery

NOT GOOD ENOUGH! Survivors want 100% recovery! GET THERE!

Will you stop pushing your tyranny of low expectations? You'll want full recovery when you become the 1 in 4 per WHO that has a stroke! You better start that research now, or you'll be disabled like most of the 10 million yearly stroke survivors.

Faster Reperfusion Linked to Better Stroke Recovery

Rapid FP recanalization boosted stroke recovery, mainly due to shorter procedure times rather than full reperfusion success.

Researchers conducted a retrospective study published in July 2025 issue of Journal of Neurology to determine whether the benefits of first pass (FP) stroke recanalization were primarily associated with complete reperfusion or shorter procedure times.

They used data from 3,707 individuals with middle cerebral artery occlusion who achieved successful recanalization (modified Thrombolysis in Cerebral Infarction [mTICI] 2b or higher), drawn from the German Stroke Registry (GSR) (2015–2021). A good functional outcome was defined as a modified Rankin Scale (mRS) score of ≤ 2 at 90 days. The mediation analysis was applied to assess how much complete reperfusion (mTICI 3) and reduced groin puncture contributed to recanalization time and outcome improvement.

The results showed that FP recanalization was linked to significantly better functional outcomes, with 46.9% of individuals in the FP group reaching a mRS score of ≤ 2 at 90 days, compared to 37.2% in those who underwent multiple thrombectomy attempts. Mediation analysis revealed that 14% of the benefit associated with FP recanalization was due to higher rates of complete reperfusion mTICI 3, while 37% was explained by shorter groin puncture to recanalization times.

Investigators concluded that the improved outcomes linked to FP recanalization were mainly driven by faster reperfusion rather than the extent of complete recanalization.

Source: link.springer.com/article/10.1007/s00415-025-13235-5