Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, December 28, 2010

nanoparticles and stroke rehab

Since I think too much about all things stroke related I came across nanoparticles and tried to envision what use they could be for stroke rehab.
They have several interesting abilities;
1. They can cross the blood-brain barrier
http://www.ncbi.nlm.nih.gov/pubmed/16154222
2. They are already used to treat thrombi in parts of the body.
http://www.springerlink.com/content/vj1528n166147410/
3. They can be magnetically directed.
http://www.redorbit.com/news/video/health/4/magnetic_nanoparticles_remotely_control_neurons_and_animal_behavior/32320/
For our purposes they could be used to deliver a clot-busting drug directly to the clot using the magnetic properties to guide it. And since the amount could be sized to the clot size the risk of bleeding could be lowered significantly and the 3-4.5 hour window for tPA ignored.
The more interesting delivery mechanism would be to deliver neuronal growth factors, c3a peptides and NOGO receptors to the penumbra and dead brain areas. Or deliver stem cells to the most likely place for them to survive and start working.
And after we deliver these growth factors or stem cells we can use connectomics to find out if they are working as we expected.

This could be incredibly useful for those who need some magical properties in order to recover, not all of us are willing to spend the rest of our lives working on recovery or have the mental cognition to understand the work needed to recover.
Posted by at
Labels: , , ,

No comments:

Post a Comment

Subscribe to: Post Comments (Atom)