Deans' stroke musings: Nanoparticles home in on human tumors growing in mice’s brains, increase accuracy of surgical removal

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, April 15, 2012

Nanoparticles home in on human tumors growing in mice’s brains, increase accuracy of surgical removal

With an innovative stroke researcher we could use the same technology to deliver drugs that stop the cascade of neuronal death and deliver stem cells to the damaged area. :Rant-On:

And then we might actually get closer to 100% recovery. :Rant-Off:

http://scopeblog.stanford.edu/2012/04/nanoparticles-home-in-on-human-tumors-growing-in-mices-brains-increase-accuracy-of-surgical-removal/
Like special-forces troops laser-tagging targets for a bomber pilot, tiny particles that home in on malignant brain tumors, such as glioblastoma, may someday enable neurosurgeons to remove these malignancies with unprecedented accuracy.
As I wrote in my release about a new study just published in Nature Medicine by Stanford radiology chief Sam Gambhir, MD, PhD, and his colleagues:

The prognosis for glioblastoma is bleak: the median survival time without treatment is three months. Surgical removal of such tumors — a virtual imperative whenever possible — prolongs the typical patient’s survival by less than a year. One big reason for this is that it is almost impossible for even the most skilled neurosurgeon to remove the entire tumor while sparing normal brain.

It’s thought that microscopic remnants of the particularly rough-edged – and particularly nasty – brain tumors called glioblastomas may be largely responsible for this tumor’s ultimate recalcitrance to surgical removal.
Gambhir and his teammates have engineered brain-tumor-seeking particles measuring less than five one-millionths of an inch in diameter – about one-sixtieth that of a human red blood cell. These particles’ gold centers are coated with materials that, in the study, made it possible to do three things: (1) preoperatively locate a human glioblastoma tumor growing in a mouse’s brain; (2) envision the tumor mass the as it’s being excised; and (3) importantly, guide the scalpel immediately afterward in the removal of myriad minuscule tentacles that snake outward from these tumors’ bulk to invade healthy surrounding tissue. Similarly, the nanoparticles highlighted isolated microscopic tumor-cell patches, called micrometastases, dotting otherwise healthy tissue. Normally, these would have been invisible to the surgeon’s naked eye, and thus might have lived to recur another day.
Previously: Nanomedicine moves one step closer to reality