http://onlinelibrary.wiley.com/doi/10.1002/ana.23593/abstract
Abstract
Objective:
A study was undertaken to relate dietary fat types to cognitive change in healthy community-based elders.
Methods:
Among
6,183 older participants in the Women's Health Study, we related intake
of major fatty acids (saturated [SFA], monounsaturated [MUFA], total
polyunsaturated [PUFA], trans-unsaturated) to late-life
cognitive trajectory. Serial cognitive testing, conducted over 4 years,
began 5 years after dietary assessment. Primary outcomes were global
cognition (averaging tests of general cognition, verbal memory, and
semantic fluency) and verbal memory (averaging tests of recall). We used
analyses of response profiles and logistic regression to estimate
multivariate-adjusted differences in cognitive trajectory and risk of
worst cognitive change (worst 10%) by fat intake.
Results:
Higher SFA intake was associated with worse global cognitive (p for linear trend = 0.008) and verbal memory (p
for linear trend = 0.01) trajectories. There was a higher risk of worst
cognitive change, comparing highest versus lowest SFA quintiles; the
multivariate-adjusted odds ratio (OR) with 95% confidence interval (CI)
was 1.64 (1.04–2.58) for global cognition and 1.65 (1.04–2.61) for
verbal memory. By contrast, higher MUFA intake was related to better
global cognitive (p for linear trend < 0.001) and verbal memory (p
for linear trend = 0.009) trajectories, and lower OR (95% CI) of worst
cognitive change in global cognition (0.52 [0.31–0.88]) and verbal
memory (0.56 [0.34–0.94]). Total fat, PUFA, and trans-fat intakes were not associated with cognitive trajectory.
Interpretation:
Higher
SFA intake was associated with worse global cognitive and verbal memory
trajectories, whereas higher MUFA intake was related to better
trajectories. Thus, different consumption levels of the major specific
fat types, rather than total fat intake itself, appeared to influence
cognitive aging. ANN NEUROL 2012;
http://www.drjohnm.org/2012/05/cycling-wed-will-eating-nuts-make-you-smarter/
http://www.drjohnm.org/2012/05/cycling-wed-will-eating-nuts-make-you-smarter/
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