Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, November 12, 2012

The role of microglia in neurogenesis: exercise and aging as cofactors

Ask your doctor if this paper tells enough about how to make sure new neurons survive and migrate to damaged areas.
http://www.futuremedicine.com/doi/abs/10.2217/fnl.12.71?journalCode=fnl
Vukovic et al. took an innovative approach to determine that microglia play a significant role in the neurogenesis that occurs in the hippocampus following physical exercise. They further demonstrated that signaling through the fractalkine ligand–receptor (CX3CL1–CX3CR1) pathway is a key mechanism through which microglia confer these neuroprotective effects. When either CX3CL1 or CX3CR1 are reduced or dysregulated, neural precursor cell activation is reduced. Physical exercise was shown to be a robust intervention to elevate CX3CL1 levels in the hippocampus of both adult and aged mice. Activated microglia in aged subjects is associated with a neuroinflammatory phenotype, and when they are depleted from neurosphere cultures, neurogenesis is robustly enhanced, suggesting that interventions that reduce microglial activation in aged subjects are of upmost benefit for the sake of preserving critical hippocampal functions such as learning and memory.

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