Get those clinical trials going. Your doctor has a job to do, insist they do it.
http://www.sciencecodex.com/diabetes_drug_may_reduce_brain_damage_after_stroke-103166
In a study in mice, scientists at Karolinska Institutet in Sweden
have discovered a new potential therapy that may reduce brain damage
following stroke in type 2 diabetic patients. The suggested drug is
already approved for the treatment of type 2 diabetes. However, the
scientists hope that this new results, presented in the scientific
journal Diabetes, also opens up the possibility to decrease brain injury after stroke in other patient groups with a high stroke risk.
Stroke is when part of the neural tissue in the brain is damaged due
to lack of oxygen delivery, either caused by a blood clot (thrombosis)
or rupture of a blood vessel. People suffering from diabetes are at
higher risk to develop stroke than the average population. The only
acute treatment to decrease the consequences (disability) of a stroke
commonly available is thrombolysis, which dissolves the blood clot in
the occluded vessels of the brain when quickly administered after onset
of symptoms.
However, this therapy is only available for approximately 10 per cent
of stroke patients and has potential severe side effects, mainly brain
hemorrhage. Furthermore, the effect of thrombolysis treatment is reduced
in diabetic patients as diabetes in itself causes a sensitive vessel
structure.
The chemical substance at the basis of the current finding is called
linagliptin, and is already commercialized as an antidiabetic drug under
a trade name. Combined with exercise and special diet, linagliptin
lowers the levels of glucose in the blood in adults with type 2
diabetes. In their study, the scientists administered linagliptin or
placebo to diabetic mice, before and after having induced a stroke
experimentally. By using this study design, the scientists simulated the
situation of type 2 diabetic patients under the treatment of
linagliptin.
The results show that linagliptin is able to stimulate
neuroprotection and largely reduce the brain damage following stroke,
independent of its glucose-lowering effects. This in turn suggests that
type 2 diabetic patients, when treated with linagliptin, might have a
better prognosis after a stroke than diabetics receiving other
treatments.
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