We're going to need this so get your doctor pushing for clinical trials. You do expect your doctor to initiate stuff like this, don't you?
http://www.sciencecodex.com/uga_research_offers_new_targets_for_stroke_treatments-104253
New research from the University of Georgia identifies the mechanisms responsible for regenerating blood vessels in the brain.
Looking for ways to improve outcomes for stroke patients, researchers
led by the UGA College of Pharmacy assistant dean for clinical programs
Susan Fagan used candesartan, a commonly prescribed medication for
lowering blood pressure, to identify specific growth factors in the
brain responsible for recovery after a stroke.
The results were published online Dec. 4 in the Journal of Pharmacology and Experimental Therapeutics.
Although candesartan has been shown to protect the brain after a
stroke, its use is generally avoided because lowering a person's blood
pressure quickly after a stroke can cause problems—like decreasing
much-needed oxygen to the brain—during the critical period of time
following a stroke.
"The really unique thing we found is that candesartan can increase
the secretion of brain derived neurotrophic factor, and the effect is
separate from the blood pressure lowering effect," said study coauthor
Ahmed Alhusban, who is a doctoral candidate in the College of Pharmacy.
"This will support a new area for treatments of stroke and other brain
injury."
Alhusban and Fagan worked with Anna Kozak, a research scientist in
the college, and Adviye Ergul, a professor and director of the
physiology graduate program at Georgia Health Sciences University. They
are the first to show that the positive effects of candesartan on brain
blood vessel growth are caused by brain derived neurotrophic factor, or
BDNF.
The research shows that when candesartan blocks the angiotensin II
type 1 receptor, which lowers blood pressure, it stimulates the AT2
receptor and increases the secretion of BDNF, which encourages brain
repair through the growth of new blood vessels.
"BDNF is a key player in learning and memory," said Fagan, the Albert
W. Jowdy Professor. "A reduction of BDNF in the brain has been
associated with Alzheimer's disease and depression, so increasing this
growth factor with a common medication is exciting."
AT2 is a brain receptor responsible for angiogenesis, or the growth
of new blood vessels from pre-existing vessels. Angiogenesis is a normal
and vital process in human growth and development—as well as in
healing.
For the study, the investigators used both living rat models and
human brain cells. Groups were treated with either a low or high dose of
angiotensin II alone or in combination with a dose of candesartan.
Candesartan promoted angiogenesis, but this effect was entirely
prevented by blocking BDNF or inactivating the AT2 receptor. This method
identified the involvement of the AT2 receptor in BDNF secretion.
"This target is a key to enhance recovery and reduce the subsequent
disability in stroke victims," said Alhusban. "We know angiogenesis
proteins are upregulated in the week after a brain injury. Stimulation
of the AT2 receptor with a medication is likely to enhance this part of
the brain's own recovery mechanisms."
Medications proven to kick-start BDNF will not only benefit stroke
victims but could have a role in other brain injury, particularly
veterans with combat-related traumatic brain injuries.
There are currently medications in development activating the AT2
receptor as a mechanism for brain protection, but drug development will
take five to 10 years before such a therapy is available to the public.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,286 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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