Deans' stroke musings: Effect of dietary olive leaf extract on brain cholesterol, cholesterol ester and triglyceride levels and of brain edema in rat stroke model

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, January 17, 2013

Effect of dietary olive leaf extract on brain cholesterol, cholesterol ester and triglyceride levels and of brain edema in rat stroke model

It does require pretreatment prior to your stroke but have your researcher study the hyperacute affects
http://rjms.tums.ac.ir/browse.php?a_id=2345&sid=1&slc_lang=en
Article abstract:
Background : Brain injury by transient complete global brain ischemia (cardiac arrest) and regional incomplete brain ischemia (ischemic stroke) afflicts a very large number of patients with death or permanent disability. Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury.
Methods: The aim of the study was to evaluate the effect of dietary Olive Leaf Extract (OLE) on brain cholesterol, cholesterol ester and triglyceride levels as well as brain edema in rat stroke model.
Five groups, each consisting of 12 male Wistar rats, were studied. First and second groups (control and sham) received distilled water, while three treatment groups received oral olive leaf extract (OLE) for 30 days (50, 75 and 100 mg/kg/day, respectively). Two hours after the last dose, each main group was subdivided to Middle Cerebral Artery Occlusion (MCAO)-operated (n=6) and intact subgroups (n=6) for assessment of neuropathology (brain edema) and brain lipid analysis.
Results: The brain cholesterol, cholesterol ester and triglyceride levels were greater in experimental groups when compared to controls. Olive leaf extracts reduced brain edema in experimental groups of 75 and 100 mg/kg/day.
Conclusion: Our data suggest that OLE may be cerebroprotective in a rat model of ischemia-reperfusion. Further work is required to extend these observations.