tPA efficacy is appalling, total rethinking needed on how to save neurons.
tPA is the standard of care for stroke but with significant risks
In KevinMDs writeup he has this;
tPA is strongly time dependent. Because of this, good outcomes are not
guaranteed. Some researchers estimate that between 1-3 hours, every 10
minute delay results in 1 less patient having an improved disability
outcome. This suggests that only 12 of 100 patients will benefit from
the drug, while 88 will not, a figure within reported ranges of efficacy
.
Thats an appalling efficacy figure. And that is what the whole F.A.S.T. campaign is built on. Lies and more lies. Instead of trying to get everyone possible treated within the timeframes, a complete rethinking of how to save neurons needs to be done. I.E. stopping the neuronal cascade of death.
This is not to say we should stop using tPA, we need to find something that can be used after tPA because tPA does not stop the neuronal cascade of death.
1. Excitotoxicity
2. Glutamate poisoning
3. Capillaries that don't open due to pericytes
4. Inflammatory action leaking through the blood brain barrier
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 27,818 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
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