http://mcb.asm.org/content/early/2013/05/15/MCB.01610-12.abstract
ABSTRACT
The involvement of nuclear factor-kappaB
(NF-κB) in several processes in the postnatal and adult brain, ranging
from neuronal
survival to synaptogenesis and plasticity, has been
documented. In contrast, little is known about the functions of NF-κB
during embryonic brain development. It is shown
here that NF-κB is selectively activated in neocortical neural
progenitor
cells in the developing mouse telencephalon.
Blockade of NF-κB activity leads to premature cortical neuronal
differentiation
and depletion of the progenitor cell pool.
Conversely, NF-κB activation causes decreased cortical neurogenesis and
expansion
of the progenitor cell compartment. This effect is
antagonized by the pro-neuronal transcription factor Hes6, which
physically
and functionally interacts with RelA-containing
NF-κB complexes in cortical progenitor cells. In turn, NF-κB exerts an
inhibitory
effect on the ability of Hes6 to promote cortical
neuronal differentiation. These results reveal previously
uncharacterized
functions, and modes of regulation, for NF-κB and
Hes6 during cortical neurogenesis.
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