Deans' stroke musings: POLYMERIC MATERIALS FOR NEOVASCULARIZATION

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 31, 2013

POLYMERIC MATERIALS FOR NEOVASCULARIZATION

You will need to ask your doctor the difference between angiogenesis and neovascularization. A great dissertation.
https://www.ideals.illinois.edu/bitstream/handle/2142/44267/Ross_Devolder.pdf?sequence=1
Only 122 pages for your doctor.

Revascularization therapies have emerged as a promising strategy to treat various acute and

chronic wounds, cardiovascular diseases, and tissue defects

It is common to either administer proangiogenic growth factors, such as vascular endothelial growth factor (VEGF) or transplant cells that

endogenously express multiple proangiogenic factors.

Additionally, these strategies utilize a wide variety

of polymeric systems, including hydrogels and biodegradable plastics, to deliver proangiogenic factors in a sophisticated manner to maintain a sustained proangiogenic environment.

Despite some impressive results in rebuilding vascular networks, it is still

a challenging task to engineer mature and functional neovessels in

target tissues, because of the increasing complexities involved with neovascularization

applications

To resolve these challenges, this work aims to design a wide variety of proangiogenic biomaterial systems with tunable properties used for neovascularization therapies.

This thesis describes the design of several biomaterial systems used for the delivery of proangiogenic factors in neovascularization therapies, including: an electrospun/e

lectrosprayed biodegradable plastic patch used for directional blood vessel growth (Chapter 2), an alginate-

pyrrolehydrogel system that biochemically stimulates cellular endogenous proangiogenic factor expression (Chapter 3), an enzyme catalyzed alginate

pyrrole hydrogel system for VEGF delivery (Chapter 4), an

enzyme activated alginate

pyrrole hydrogel system with systematically controllable electrical and

mechanical properties (Chapter 5), and an alginate

pyrrole hydrogel that enables the decoupled control

of electrical conductivity and mechanical rigidity and is use to electrically stimulate cellular endogenous proangiogenic factor expression (Chapter 6). Overall, the

biomaterial systems developed in this thesis

will be broadly useful for improving the quality of a wide array of molecular and cellular

based revascularization therapies