http://stroke.ahajournals.org/content/44/6/e65
Introduction
Gamma aminobutyric acid (GABA)
receptor agonists have shown to be effective in reducing infarct size
and improving functional
outcome in animal models of cerebral
ischemia. However, the sedation effects of GABA receptor agonists
limited the application
in acute stroke patients because of the
potential risk of stupor.
Materials and Methods
Objective
The aim of this study is to determine the efficacy and safety of GABA receptor agonists in the treatment of acute stroke.
Types of Studies
Randomized controlled trials.
Types of Participants
Acute stroke patients within 12 hours after stroke onset.
Types of Interventions
GABA receptor agonists in comparison with placebo.
Primary Outcomes
Death or dependency, defined as a Barthel Index score of ≤60, or the modified Rankin Scale graded 3 to 5, and adverse events.
Secondary Outcomes
Functional independence, defined
as Barthel Index score >60, or modified Rankin Scale <3, and
neurological function measured
by other stroke scales.
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