Someone who isn't bamboozled the the tPA aura.
http://www.theguardian.pe.ca/News/Local/2013-05-29/article-3264069/Made-in-P.E.I.-drug-aims-to-ease-strokes/1
Stroke victims could some day get help from a made-in-P.E.I. drug as
Atlantic Veterinary College researchers move closer to trying it out on
human patients.
Professor Tarek Saleh’s lab developed a compound to protect the brain
during a stroke and recently signed a memorandum of understanding with
Mokwon University in South Korea for further research.
Saleh said he was excited to see other people interested in his lab’s work.
“It’s truly a global collaboration,” he said.
When a blood clot stops the flow of blood to the brain, it causes a stroke and cuts off oxygen to the brain.
There is a drug, called tissue plasminogen activator (TPA), available
to break up the clot, but most stroke victims can’t take it because
doctors have a small window of opportunity in which to administer it.
Only about five per cent of stroke victims are able to use the clot-busting drug.
The problem, Saleh said, is that free radicals cause damage to the brain when blood flow suddenly returns.
Saleh and his research team created a compound called UPEI-100 that
protects the brain from the free radical damage and extends the window
of opportunity for doctors to administer TPA, even if the victim doesn’t
know when they had the stroke.
The next step is proving the compound’s effectiveness and that’s where research technician Barry Connell comes in.
Connell works in a small lab at the veterinary college where injects
up to four rats a day with the compound and anesthetizes them before
inducing a stroke in them.
He does that by inserting three nylon threads under an artery in a rat’s brain to cut off the blood flow.
The threads are later removed to allow blood to flow back into the brain to simulate a clot removal.
After Connell removes the threads, he also removes the rat’s brain
and colours it with a dye to measure how much damage the stroke causes
and to determine how much protection the compound gives once blood
starts flowing again.
All of the animal testing is done under stringent controls to ensure
the test animals are treated in a responsible and ethical manner.
Saleh said those tests have shown promising results with the compound
made up of natural, plant-based products leading to reduced damage
after the blood flow returns.
It was that combination of the products that is in pre-clinical
trials and got the attention of the lab’s partners in Korea and a
bioscience company in Atlanta.
“It’s a hundred-fold more potent if you combine the compounds than if you were
to give them individually,” he said.
Trials have already shown the natural products that make up the
compound are safe for humans, but human trials for UPEI-100 as a stroke
treatment are still a few years away.
And while they know the compound created in Charlottetown works,
Saleh said his lab doesn’t know why and that’s where Mokwon University
comes in.
“That’s why we’re doing testing.”
Connell was the lab’s representative in South Korea where he
travelled in March for a ceremonial signing of the memorandum of
understanding.
When he was there, he was treated like royalty with TV, newspaper and
radio outlets all there to cover the signing, Connell said.
“It was more than ... I could ever hope could have come out of the work that we do.”
Connell said he has been working in a lab doing research for 35 years
and is finally seeing something he helped develop with potential to
lead to more than just a scientific paper.
“It’s incredible,” he said.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,116 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Thursday, May 30, 2013
Made-in-P.E.I. drug aims to ease strokes
Labels:
Canada,
clinical trials,
hyperacute,
radicals,
tPA,
UPEI-100
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