Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,286 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Friday, May 24, 2013
Dopamine restores reward prediction errors in old age
Senescence affects the ability to utilize information about
the likelihood of rewards for optimal decision-making. Using functional
magnetic resonance imaging in humans, we found that healthy older adults
had an abnormal signature of expected value, resulting in an incomplete
reward prediction error (RPE) signal in the nucleus accumbens, a brain
region that receives rich input projections from substantia
nigra/ventral tegmental area (SN/VTA) dopaminergic neurons. Structural
connectivity between SN/VTA and striatum, measured by diffusion tensor
imaging, was tightly coupled to inter-individual differences in the
expression of this expected reward value signal. The dopamine precursor
levodopa (L-DOPA) increased the task-based learning rate and task
performance in some older adults to the level of young adults. This drug
effect was linked to restoration of a canonical neural RPE. Our results
identify a neurochemical signature underlying abnormal reward
processing in older adults and indicate that this can be modulated by
L-DOPA
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