Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, December 3, 2014

Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome?

Is CFS close enough to stroke fatigue to possibly be able to use the same interventions? Tell your doctor to find out. Do not self-prescribe.
http://online.liebertpub.com/doi/abs/10.1089/ars.2014.6181
Dr. JESUS CASTRO-MARRERO, Ph.D.
Vall de Hebron Univ Hospital Research Institute, CFS Research Unit,
PASSEIG DE VALL DE HEBRON, 119-129
,
PASSEIG DE VALL DE HEBRON, 119-129
, BARCELONA, Barcelona, Spain,
08035
, 934893000 (EXT. 4927), 932746708;
Prof. Mario D. Cordero
Research Laboratory, Dental School, Universidad de Sevilla, Sevilla, Spain,
C/Avicena s/n
, Sevilla, Spain,
41009
, +34 954 481120, +34 954 486784;
Dr. Maria Jose jesus.castro@vhir.org Segundo
Vitae Natural Nutrition, SL, Research and Development (R&D), BARCELONA, Sant Cugat del Vallès, Spain;
Naia Saez-Francas
Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Departamento de Psiquiatría y Medicina Legal, BARCELONA, BARCELONA, Spain;
Dr. Natalia Calvo
Vall d'Hebron University Hospital, Departamento de Psiquiatría y Medicina Legal, BARCELONA, BARCELONA, Spain;
Dr. Lourdes Román-Malo
Dental School University of Sevilla, Research Laboratory, SEVILLA, SEVILLA, Spain;
Luisa Aliste
Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain;
Prof. Tomas Fernandez de Sevilla
Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain;
Dr. Jose Alegre-Martin
Vall d'Hebron University Hospital, CFS Clinical Unit, BARCELONA, BARCELONA, Spain;
Accepted: November 03 2014
Received: November 03 2014

ABSTRACT

Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. We conducted an 8-weeks randomized, double-blind, placebo-controlled trial to evaluate the benefits of oral CoQ10 (200 mg/day) plus NADH (20 mg/day) supplementation on fatigue and biochemical parameters in 73 Spanish CFS patients. This study was registered in ClinicalTrials.gov (NCT02063126). A significant improvement of fatigue showing a reduction in FIS total score (p< 0.05) was reported in treated group vs. placebo. In addition, a recovery of the biochemical parameters was also reported. NAD+/NADH (p< 0.001), CoQ10 (p< 0.05), ATP (p< 0.05) and citrate synthase (p< 0.05) were significantly higher and lipoperoxides (p< 0.05) were significantly lower in blood mononuclear cells (BMCs) of the treated group. These observations lead to the hypothesis that the oral CoQ10 plus NADH supplementation could confers potential therapeutic benefits on fatigue and biochemical parameters in CFS. Larger sample trials are warranted to confirm these findings.
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