http://www.medpagetoday.com/Cardiology/Strokes/49257
A novel agent to mitigate adverse effects of stroke thrombolytics decreased the risk of intracranial hemorrhage and improved recovery, according to top-line results from a phase II trial.
Called THR-18, the investigational drug was associated with no cases of intracranial hemorrhage found on CT imaging 2 days after being given with tissue plasminogen activator (tPA) for acute ischemic stroke in the small trial (P=0.02 versus placebo), developer D-Pharm announced.
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The higher of the two doses of the agent tested in the
trial (0.54 mg/kg) doubled the recovery rate at 30 days as assessed by
either neurologic deficit measured with the NIH stroke scale score or
disability in activities of daily living on the modified Rankin Scale.More at link.
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