http://nnr.sagepub.com/content/early/2014/11/21/1545968314562113?papetoc
- Elizabeth R. Skidmore, PhD1
- Deirdre R. Dawson, PhD2,3
- Meryl A. Butters, PhD1,4
- Emily S. Grattan, MS1
- Shannon B. Juengst, PhD1
- Ellen M. Whyte, MD1,4
- Amy Begley, MA1,4
- Margo B. Holm, PhD1
- James T. Becker, PhD1
- 1University of Pittsburgh, Pittsburgh, PA, USA
- 2Rotman Research Institute at Baycrest, Toronto, Ontario, Canada
- 3University of Toronto, Toronto, Ontario, Canada
- 4Western Psychiatric Institute & Clinic, Pittsburgh, PA, USA
- Elizabeth Skidmore, Department of Occupational Therapy, University of Pittsburgh, 5012 Forbes Tower, Pittsburgh, PA 15260, USA. Email: skidmore@pitt.edu
Abstract
Background. Cognitive impairments occur frequently after stroke and contribute to significant disability. Strategy training shows promise
but has not been examined in the acute phase of recovery. Objective.
We conducted a single-blind randomized pilot study estimating the
effect of strategy training, relative to reflective listening
(attention control), for reducing disability and
executive cognitive impairments. Methods. Thirty participants
with acute stroke who were enrolled in inpatient rehabilitation and had
cognitive impairments were randomized
to receive strategy training (n = 15, 10 sessions
as adjunct to usual inpatient rehabilitation) or reflective listening (n
= 15, same dose). The Functional Independence
Measure assessed disability at baseline, rehabilitation discharge, 3,
and 6
months. The Color Word Interference Test of the
Delis–Kaplan Executive Function System assessed selected executive
cognitive
impairments (inhibition, flexibility) at baseline,
3, and 6 months. Results. Changes in Functional Independence Measure scores for the 2 groups over 6 months showed significant effects of group (F1,27 = 9.25, P = .005), time (F3,74 = 96.00, P < .001), and group * time interactions (F3,74 = 4.37, P < .007) after controlling for baseline differences in stroke severity (F1,27 = 6.74, P = .015). Color Word Interference Inhibition scores showed significant effects of group (F1,26 = 6.50, P = .017) and time (F2,34 = 4.74, P = .015), but the group * time interaction was not significant (F2,34 = 2.55, P = .093). Color Word Interference Cognitive Flexibility scores showed significant effects of group (F1,26 = 23.41, P < .001), time (F2,34 = 12.77, P < .001), and group * time interactions (F2,34 = 7.83, P < .002). Interaction effects suggested greater improvements were associated with strategy training. Conclusions. Strategy training shows promise for addressing disability in the first 6 months after stroke. Lessons from this pilot study
may inform future clinical trials.
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