Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, December 17, 2014

SPINAL CORD INJURY Sprouting Neurological Function

Would this be useful after our strokes?
http://stm.sciencemag.org/content/6/267/267ec216.full?utm_source=eloqua
  1. Daniel K. Nishijima
+ Author Affiliations
  1. Department of Emergency Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA. E-mail: daniel.nishijima@ucdmc.ucdavis.edu
Injury to the spinal cord, the main information highway up and down the body, triggers upregulation of highly glycosylated proteins at the site of injury. This acts as a barrier to nerve regeneration and “traps” nerves’ growing tips, preventing neurological recovery. Lang et al. developed an inhibitor that interferes with proteoglycan binding to its receptor [protein tyrosine phosphatase σ (PTPσ)] and is able to reverse the nerve regrowth blockage after spinal cord injury and improve the animals’ functional recovery.
Rats with spinal cord injury were injected with the PTPσ-binding drug subcutaneously daily for several weeks. At the end of treatment, urinary function and walking were improved compared with control animals, with higher doses producing better urinary function. Unexpectedly, the researchers did not observe regeneration of corticospinal tract fibers through the injury in the treated rats. Rather, below the lesion, they saw significant sprouting of dense territories of serotonergic neurons. Treatment with a serotonin antagonist reduced locomotor and urinary function in the treatment group but not the control group. This result indicated that the neurological improvement was a result of increased serotonin production from sprouting and regrowth of nerves that survived the injury rather than of reconnections of injured nerve fibers.
The practical advantage of delivering the drug systemically and the positive results of this study suggest that this approach holds great potential as a treatment for patients with spinal cord injury.
B. T. Lang et al., Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury. Nature 10.1038/nature13974 (2014). [Abstract]

No comments:

Post a Comment