Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, March 17, 2015

Research on injectable oriented hydrogels for spinal cord repair - Maybe stroke?

And with a great stroke association following up on promising research this would be looked at to repurpose it for stroke repair. We need to repair 12 km (7.5 miles) of connections for each minute of infarct. But nothing will occur.

Research on injectable oriented hydrogels for spinal cord repair - Maybe stroke?


The research objective of Dr.-Ing. Laura De Laporte, junior group leader at DWI – Leibniz Institute for Interactive Materials in Aachen, is to develop a minimally invasive therapy for spinal cord injury. Her goal and her scientific approach to develop an injectable material with the ability to provide biochemical and physical guidance for regenerating nerves across the injury site, was selected by the European Research Council (ERC). Laura De Laporte now receives a 1.5 Million Euro ERC Starting Grant for her project ANISOGEL.
Spinal cord injury affects approximately two million people worldwide and is devastating as it leads to a loss of motor and sensory function below the point of injury. Regenerative therapies therefore try to restore nerve tracts and their function. Human neural stem cells or oligodendrocytes, which form the myelin sheet around the nerve cells, have been successfully transplanted into the damaged area and have created a spark of hope. To support these transplanted and other native cells at the injury site, and to guide neuron growth across this area, scientists are also investigating nerve bridges that are made of biomaterials, provide functional domains, and release growths factors. Unfortunately, such implants still face the challenge to stimulate the growing nerves to cross the point of injury and reenter the healthy spinal cord to rebuild functional connections.
In her project ANISOGEL, Laura De Laporte will engineer an injectable biomaterial that can be used as a matrix for a minimally invasive therapy to support oriented regeneration of damaged nerves. The material is based on a soft, water-rich polymeric network (hydrogel), which gels in situ and can be designed to mimic the conditions of the natural cell environment. The physical, chemical, and biological properties of these gels can be tailored bottom-up to resemble the body’s own extracellular matrix that provides mechanical and biological support to the cells.
“A hydrogel-based approach is not new. The innovative aspect about ANISOGEL is that we want to synthesize a material that can be hierarchically structured and form an anisotropic architecture in situ,” explains De Laporte. “This will improve the cells’ spatial orientation, which is crucial for nerve repair. The hydrogel will be further modified with biological signaling molecules to create an environment that stimulates cellular processes necessary for spinal cord regeneration and to regain functionality.”
Laura De Laporte received her Masters in Chemical Engineering at the University of Ghent and obtained her PhD in the laboratory of Prof. Lonnie Shea at Northwestern University in the United States. There, she focused on the development of multiple channel bridges with the ability for DNA and protein delivery for spinal cord repair. As a post-doctoral researcher at EPFL (Switzerland) in the laboratory of Prof. Jeffrey Hubbell, she engineered extracellular matrix-like hydrogels for tissue and nerve repair. She started her junior research group at DWI in October 2013. With the ERC Starting Grant, the European Research Council supports her work for the next five years.

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